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Jian, X, Wasinger, EC, Lockard, JV, Chen, LX and He, C (2009) Highly sensitive and selective gold(I) recognition by a metalloregulator in Ralstonia metallidurans. J. Am. Chem. Soc. 131:10869-71
A MerR family metalloregulatory protein CupR selectively responds to gold stress in Ralstonia metallidurans. A distorted trigonal geometry appears to be used by CupR to achieve the highly sensitive (K(d) approximately 10(-35) M) and selective recognition of gold(I).
Bacterial Proteins/metabolism; Gold/pharmacokinetics; Protein Binding; Ralstonia/metabolism
|Gene product||Qualifier||GO Term||Evidence Code||with/from||Aspect||Extension||Notes||Status|
|GO:0071248: cellular response to metal ion||
Figure 2: Northern Blot analysis shows induction of cupR in the presence of gold ions. Expression is increased with increased gold concentration. No GO term for "response to gold ion" available.
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