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PMID:19543268

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Citation

Karner, CM, Chirumamilla, R, Aoki, S, Igarashi, P, Wallingford, JB and Carroll, TJ (2009) Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis. Nat. Genet. 41:793-9

Abstract

Although many vertebrate organs, such as kidneys, lungs and liver, are composed of epithelial tubules, little is known of the mechanisms that establish the length or diameter of these tubules. In the kidney, defects in the establishment or maintenance of tubule diameter are associated with one of the most common inherited human disorders, polycystic kidney disease. Here we show that attenuation of Wnt9b signaling during kidney morphogenesis affects the planar cell polarity of the epithelium and leads to tubules with significantly increased diameter. Although previous studies showed that polarized cell divisions maintain the diameter of postnatal kidney tubules, we find that cell divisions are randomly oriented during embryonic development. Our data suggest that diameter is established during early morphogenetic stages by convergent extension processes and maintained by polarized cell divisions. Wnt9b, signaling through the non-canonical Rho/Jnk branch of the Wnt pathway, is necessary for both of these processes.

Links

PubMed PMC2761080 Online version:10.1038/ng.400

Keywords

Animals; Cell Polarity; Female; Gene Expression Regulation, Developmental; Kidney/cytology; Kidney/growth & development; Kidney Tubules/cytology; Kidney Tubules/growth & development; Male; Signal Transduction; Wnt Proteins/genetics; Wnt Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0001932: regulation of protein phosphorylation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3526437

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0001822: kidney development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0009786: regulation of asymmetric cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3805020

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0060071: Wnt signaling pathway, planar cell polarity pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3526437

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0043085: positive regulation of catalytic activity

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3526437

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0072078: nephron tubule morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3526437
MGI:MGI:3805020

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0072046: establishment of planar polarity involved in nephron morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3526437
MGI:MGI:3805020

P

Seeded From UniProt

complete

MOUSE:WNT9B

acts_upstream_of_or_within

GO:0035150: regulation of tube size

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3526437
MGI:MGI:3805020

P

Seeded From UniProt

complete

MOUSE:RHOD

enables

GO:0005525: GTP binding

ECO:0000314: direct assay evidence used in manual assertion

F

  • occurs_in:(EMAPA:17373)

Seeded From UniProt

complete


See also

References

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