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PMID:19520787

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Citation

Burnicka-Turek, O, Shirneshan, K, Paprotta, I, Grzmil, P, Meinhardt, A, Engel, W and Adham, IM (2009) Inactivation of insulin-like factor 6 disrupts the progression of spermatogenesis at late meiotic prophase. Endocrinology 150:4348-57

Abstract

Insulin-like factor 6 (INSL6), a member of the insulin-like superfamily, is predominantly expressed in male germ cells. Expression of the Insl6 is first detected in mouse testis at postnatal d 15 when the first wave of spermatogenesis progresses to pachytene spermatocytes. To elucidate the role of INSL6 in germ cell development, we generated Insl6-deficient mice. The majority of the Insl6-deficient males on a hybrid genetic background exhibited impaired fertility, whereas females were fertile. The number of mature sperm and sperm motility were drastically reduced in the epididymis. The reduced sperm count could be due to apoptotic death of a significant number of developing germ cells. Analysis of germ cell development during the juvenile life showed an arrest of the first wave of spermatogenesis in late meiotic prophase. RNA analysis revealed a significant decrease in expression of late meiotic- and postmeiotic-specific marker genes, whereas expression of early meiotic-specific genes remains unaffected in the Insl6(-/-) testes. These results demonstrate that INSL6 is required for the progression of spermatogenesis.

Links

PubMed Online version:10.1210/en.2009-0201

Keywords

Animals; Gene Expression; Germ Cells/pathology; Infertility, Male/genetics; Intracellular Signaling Peptides and Proteins/deficiency; Intracellular Signaling Peptides and Proteins/physiology; Male; Meiotic Prophase I/drug effects; Mice; Spermatogenesis/genetics; Spermatogenesis/physiology; Testis/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:INSL6

acts_upstream_of_or_within

GO:0030317: flagellated sperm motility

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4431170

P

Seeded From UniProt

complete

MOUSE:INSL6

acts_upstream_of_or_within

GO:0008584: male gonad development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4431170

P

  • results_in_development_of:(EMAPA:17972)

Seeded From UniProt

complete

MOUSE:INSL6

acts_upstream_of_or_within

GO:0007286: spermatid development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4431170

P

  • occurs_in:(CL:0000015)

Seeded From UniProt

complete

MOUSE:INSL6

acts_upstream_of_or_within

GO:0007283: spermatogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4431170

P

Seeded From UniProt

complete

MOUSE:INSL6

acts_upstream_of_or_within

GO:0009566: fertilization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4431170

P

Seeded From UniProt

complete

MOUSE:INSL6

acts_upstream_of_or_within

GO:0043066: negative regulation of apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:4431170

P

  • regulates_o_occurs_in:(CL:0000015)
  • regulates_o_occurs_in:(EMAPA:17972)

Seeded From UniProt

complete


See also

References

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