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PMID:19464344

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Citation

Yanicostas, C, Herbomel, E, Dipietromaria, A and Soussi-Yanicostas, N (2009) Anosmin-1a is required for fasciculation and terminal targeting of olfactory sensory neuron axons in the zebrafish olfactory system. Mol. Cell. Endocrinol. 312:53-60

Abstract

The KAL-1 gene underlies the X-linked form of Kallmann syndrome (KS), a neurological disorder that impairs the development of the olfactory and GnRH systems. KAL-1 encodes anosmin-1, a cell matrix protein that shows cell adhesion, neurite outgrowth, and axon-guidance and -branching activities. We used zebrafish embryos as model to better understand the role of this protein during olfactory system (OS) development. First, we detected the protein in olfactory sensory neurons from 22 h post-fertilization (hpf) onward, i.e. prior their pioneer axons reached presumptive olfactory bulbs (OBs). We found that anosmin-1a depletion impaired the fasciculation of olfactory axons and their terminal targeting within OBs. Last, we showed that kal1a inactivation induced a severe decrease in the number of GABAergic and dopaminergic OB neurons. Though the phenotypes induced following anosmin-1a depletion in zebrafish embryos did not match precisely the defects observed in KS patients, our results provide the first demonstration of a direct requirement for anosmin-1 in OS development in vertebrates and stress the role of OB innervation on OB neuron differentiation.

Links

PubMed Online version:10.1016/j.mce.2009.04.017

Keywords

Animals; Animals, Genetically Modified/embryology; Animals, Genetically Modified/metabolism; Axons/metabolism; Brain/embryology; Brain/metabolism; Brain/pathology; Embryo, Nonmammalian/innervation; Embryo, Nonmammalian/metabolism; Gene Expression Regulation, Developmental; Image Processing, Computer-Assisted; In Situ Hybridization, Fluorescence; Interneurons/metabolism; Interneurons/pathology; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nerve Tissue Proteins/physiology; Neurogenesis/genetics; Olfactory Bulb/embryology; Olfactory Bulb/metabolism; Olfactory Bulb/pathology; Olfactory Mucosa/embryology; Olfactory Mucosa/metabolism; Olfactory Mucosa/pathology; Olfactory Pathways/embryology; Olfactory Pathways/metabolism; Olfactory Receptor Neurons/embryology; Olfactory Receptor Neurons/metabolism; Oligodeoxyribonucleotides, Antisense/metabolism; Protein Transport; Sensory Receptor Cells/classification; Sensory Receptor Cells/metabolism; Sensory Receptor Cells/pathology; Time Factors; Zebrafish/embryology; Zebrafish/genetics; Zebrafish/metabolism; Zebrafish Proteins/deficiency; Zebrafish Proteins/genetics; Zebrafish Proteins/metabolism; Zebrafish Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0B5JS68

involved_in

GO:0021772: olfactory bulb development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:A0A0B5JS68

involved_in

GO:0007411: axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:A0A0B5JS68

involved_in

GO:0071542: dopaminergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:A0A0B5JS68

involved_in

GO:0097155: fasciculation of sensory neuron axon

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:A0A0B5JS68

involved_in

GO:0097154: GABAergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:F1R469

involved_in

GO:0021772: olfactory bulb development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:F1R469

involved_in

GO:0007411: axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:F1R469

involved_in

GO:0071542: dopaminergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:F1R469

involved_in

GO:0097155: fasciculation of sensory neuron axon

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:F1R469

involved_in

GO:0097154: GABAergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q6P938

involved_in

GO:0021772: olfactory bulb development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q6P938

involved_in

GO:0007411: axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q6P938

involved_in

GO:0071542: dopaminergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q6P938

involved_in

GO:0097155: fasciculation of sensory neuron axon

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q6P938

involved_in

GO:0097154: GABAergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q9IAR4

involved_in

GO:0021772: olfactory bulb development

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q9IAR4

involved_in

GO:0007411: axon guidance

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q9IAR4

involved_in

GO:0071542: dopaminergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q9IAR4

involved_in

GO:0097155: fasciculation of sensory neuron axon

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete

DANRE:Q9IAR4

involved_in

GO:0097154: GABAergic neuron differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-081216-1

P

Seeded From UniProt

complete


See also

References

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