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PMID:19458328

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Citation

Skarie, JM and Link, BA (2009) FoxC1 is essential for vascular basement membrane integrity and hyaloid vessel morphogenesis. Invest. Ophthalmol. Vis. Sci. 50:5026-34

Abstract

Alterations in FOXC1 dosage lead to a spectrum of highly penetrant, ocular anterior segment dysgenesis phenotypes. The most serious outcome is the development of glaucoma, which occurs in 50% to 75% of patients. Therefore, the need to identify specific pathways and genes that interact with FOXC1 to promote glaucoma is great. In this study, the authors investigated the loss of foxC1 in the zebrafish to characterize phenotypes and gene interactions that may impact glaucoma pathogenesis.

Links

PubMed Online version:10.1167/iovs.09-3447

Keywords

Animals; Basement Membrane/blood supply; Basement Membrane/metabolism; Basement Membrane/pathology; Biological Markers/metabolism; Endothelium, Vascular/metabolism; Endothelium, Vascular/pathology; Eye/embryology; Fluorescein Angiography; Fluorescent Antibody Technique, Indirect; Forkhead Transcription Factors/physiology; Gene Expression; Gene Knockout Techniques; Gene Silencing; In Situ Hybridization; Laminin/metabolism; Lens, Crystalline/blood supply; Microscopy, Confocal; Microscopy, Electron, Transmission; Morphogenesis/physiology; Ophthalmic Artery/embryology; Ophthalmic Artery/metabolism; Ophthalmic Artery/pathology; Zebrafish/embryology; Zebrafish Proteins/metabolism; Zebrafish Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A0R4II20

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060520-1,ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:Q2TJF6

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060520-1,ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:Q45H72

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060520-1,ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:FXC1B

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:FXC1B

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060520-1,ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:FXC1B

involved_in

GO:0043010: camera-type eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:FXC1A

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:FXC1A

involved_in

GO:0001568: blood vessel development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-060520-1,ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete

DANRE:FXC1A

involved_in

GO:0043010: camera-type eye development

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-MRPHLNO-061111-2,ZFIN:ZDB-MRPHLNO-061111-3

P

Seeded From UniProt

complete


See also

References

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