GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com


Jump to: navigation, search

Bossi, F, Cordoba, E, Dupré, P, Mendoza, MS, Román, CS and León, P (2009) The Arabidopsis ABA-INSENSITIVE (ABI) 4 factor acts as a central transcription activator of the expression of its own gene, and for the induction of ABI5 and SBE2.2 genes during sugar signaling. Plant J. 59:359-74


The transcription factor ABA INSENSITIVE 4 (ABI4), discovered nearly 10 years ago, plays a central role in a variety of functions in plants, including sugar responses. However, not until very recently has its mechanism of action begun to be elucidated. Modulating gene expression is one of the primary mechanisms of sugar regulation in plants. Nevertheless, the transcription factors involved in regulating sugar responses and their role(s) during the signal transduction cascade remain poorly defined. In this paper we analyzed the participation of ABI4, as it is one of the main transcription factors implicated in glucose signaling during early seedling development. Our studies show that ABI4 is an essential activator of its own expression during development, in ABA signaling and in sugar responses. It is also important for the glucose-mediated expression of the genes ABI5 and SBE2.2. We demonstrate that ABI4 binds directly to the promoter region of all three genes and activates their expression in vivo through at CE1-like element. Previous studies found that ABI4 also functions as a transcriptional repressor of sugar-regulated genes, therefore this transcription factor is a versatile protein with dual functions for modulating gene expression.


PubMed Online version:10.1111/j.1365-313X.2009.03877.x


Abscisic Acid/metabolism; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Base Sequence; Basic-Leucine Zipper Transcription Factors/metabolism; Gene Expression Regulation, Plant; Glucose/metabolism; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; RNA, Plant/genetics; Seedling/growth & development; Signal Transduction; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription Initiation Site



Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status



GO:0009749: response to glucose

ECO:0000315: mutant phenotype evidence used in manual assertion


Seeded From UniProt




GO:0000976: transcription cis-regulatory region binding

ECO:0000314: direct assay evidence used in manual assertion


Seeded From UniProt


See also


See Help:References for how to manage references in GONUTS.