GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:19389360

From GONUTS
Jump to: navigation, search
Citation

Hingwing, K, Lee, S, Nykilchuk, L, Walston, T, Hardin, J and Hawkins, N (2009) CWN-1 functions with DSH-2 to regulate C. elegans asymmetric neuroblast division in a beta-catenin independent Wnt pathway. Dev. Biol. 328:245-56

Abstract

In Caenorhabditis elegans, Wnt signaling regulates many asymmetric cell divisions. During embryogenesis, the C. elegans Dishevelled (Dsh) homolog, DSH-2, regulates asymmetric neuroblast division of the ABpl/rpppa blast cell. Dsh is a key intracellular component of both beta-catenin dependent and beta-catenin independent Wnt pathways. In C. elegans, most of the well-characterized asymmetric cell divisions regulated by Wnts are dependent on beta-catenin. In the ABpl/rpppa neuroblast division, however, we determined that DSH-2 regulates cell polarity through a beta-catenin independent Wnt pathway. We also established that the C. elegans Wnt homolog, cwn-1, functions to regulate asymmetric division of the ABpl/rpppa blast cell. Our results indicated that cwn-1 does not act alone in this process, and it functions with another redundant ligand that appears not to be a Wnt. Finally, we show widespread requirements for DSH-2 during embryogenesis in the generation of many other neurons. In particular, DSH-2 function is necessary for the correct production of the embryonic ventral cord motor neurons. This study demonstrates a role for DSH-2 and Wnt signaling in neuronal specification during C. elegans embryogenesis.

Links

PubMed Online version:10.1016/j.ydbio.2009.01.025

Keywords

Animals; Animals, Genetically Modified; Body Patterning/physiology; Caenorhabditis elegans/cytology; Caenorhabditis elegans/embryology; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/physiology; Cell Cycle Proteins/genetics; Cell Cycle Proteins/physiology; Cell Division; Cell Lineage; Cell Polarity/physiology; Cytoskeletal Proteins/genetics; Cytoskeletal Proteins/physiology; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; High Mobility Group Proteins/genetics; High Mobility Group Proteins/physiology; Motor Neurons/cytology; Motor Neurons/physiology; Neurogenesis/physiology; Protein Structure, Tertiary; Signal Transduction; Transcription Factors/genetics; Transcription Factors/physiology; Wnt Proteins/genetics; Wnt Proteins/physiology; beta Catenin/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:WNT1

involved_in

GO:0001708: cell fate specification

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001102

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00094713

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0001708: cell fate specification

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000857

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0008104: protein localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0008356: asymmetric cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00094713

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0048598: embryonic morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00094713

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0048546: digestive tract morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q18239

involved_in

GO:0035262: gonad morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00094713

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.