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PMID:19344940

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Citation

Heiman, MG and Shaham, S (2009) DEX-1 and DYF-7 establish sensory dendrite length by anchoring dendritic tips during cell migration. Cell 137:344-55

Abstract

Cells are devices whose structures delimit function. For example, in the nervous system, neuronal and glial shapes dictate paths of information flow. To understand how cells acquire their shapes, we examined the formation of a sense organ in C. elegans. Using time-lapse imaging, we found that sensory dendrites form by stationary anchoring of dendritic tips during cell-body migration. A genetic screen identified DEX-1 and DYF-7, extracellular proteins required for dendritic tip anchoring, which act cooperatively at the time and place of anchoring. DEX-1 and DYF-7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into multimers important for anchoring. Thus, unlike other dendrites, amphid dendritic tips are positioned by DEX-1 and DYF-7 without the need for long-range guidance cues. In sequence and function, DEX-1 and DYF-7 resemble tectorins, which anchor stereocilia in the inner ear, suggesting that a sensory dendrite anchor may have evolved into part of a mechanosensor.

Links

PubMed PMC2673108 Online version:10.1016/j.cell.2009.01.057

Keywords

Animals; Caenorhabditis elegans/cytology; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Cell Movement; Cell Shape; Dendrites/metabolism; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neuroglia/cytology; Neurons/cytology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:DEX1

located_in

GO:0032590: dendrite membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:DEX1

involved_in

GO:0003391: amphid sensory organ dendrite retrograde extension

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00001123

P

Seeded From UniProt

complete

CAEEL:DEX1

involved_in

GO:0003391: amphid sensory organ dendrite retrograde extension

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00091405

P

Seeded From UniProt

complete

CAEEL:DYF7

located_in

GO:0032590: dendrite membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:DYF7

involved_in

GO:0003391: amphid sensory organ dendrite retrograde extension

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00044269

P

Seeded From UniProt

complete

CAEEL:DYF7

involved_in

GO:0003391: amphid sensory organ dendrite retrograde extension

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00531956
WB:WBVar00531961

P

Seeded From UniProt

complete

CAEEL:DYF7

enables

GO:0043621: protein self-association

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00001123

F

Seeded From UniProt

complete


See also

References

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