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PMID:19282511

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Citation

Yanase, S, Onodera, A, Tedesco, P, Johnson, TE and Ishii, N (2009) SOD-1 deletions in Caenorhabditis elegans alter the localization of intracellular reactive oxygen species and show molecular compensation. J. Gerontol. A Biol. Sci. Med. Sci. 64:530-9

Abstract

Superoxide dismutase (SOD) is an enzyme that catalytically removes the superoxide radical (*O2-) and protects organisms from oxidative damage during normal aging. We demonstrate that not only the cytosolic *O2- level but also the mitochondrial *O2- level increases in the deletion mutants of sod-1 gene encoding Cu/Zn SOD in Caenorhabditis elegans (C. elegans). Interestingly, this suggests that the activity of SOD-1, which so far has been thought to act mainly in cytoplasm, helps to control the detoxification of *O2- also in the mitochondria. We also found functional compensation by other SODs, especially the sod-5 gene, which was induced several fold in the mutants. Therefore, the possibility exists that the compensative expression of sod-5 gene in the sod-1 deficit is associated with the insulin/insulin-like growth factor-1 (Ins/IGF-1) signaling pathway, which regulates longevity and stress resistance of C. elegans because the sod-5 gene may be a target of the pathway.

Links

PubMed Online version:10.1093/gerona/glp020

Keywords

Animals; Caenorhabditis elegans; Gene Expression Regulation, Enzymologic; Longevity/genetics; Mitochondria/enzymology; Reactive Oxygen Species/metabolism; Superoxide Dismutase/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:SODC

involved_in

GO:0019430: removal of superoxide radicals

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00249804
WB:WBVar00249811

P

Seeded From UniProt

complete

CAEEL:SODC

located_in

GO:0005829: cytosol

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00249804
WB:WBVar00249811

C

Seeded From UniProt

complete

CAEEL:SODC

enables

GO:0004784: superoxide dismutase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00249804
WB:WBVar00249811

F

Seeded From UniProt

complete


See also

References

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