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PMID:19188444

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Citation

Blauwkamp, TA and Csankovszki, G (2009) Two classes of dosage compensation complex binding elements along Caenorhabditis elegans X chromosomes. Mol. Cell. Biol. 29:2023-31

Abstract

Dosage compensation equalizes X-linked gene products between the sexes. In Caenorhabditis elegans, the dosage compensation complex (DCC) binds both X chromosomes in XX animals and halves the transcription from each. The DCC is recruited to the X chromosomes by a number of loci, rex sites, and is thought to spread from these sites by an unknown mechanism to cover the rest of the chromosome. Here we describe a novel class of DCC-binding elements that we propose serve as "way stations" for DCC binding and spreading. Both rex sites and way stations comprise strong foci of DCC binding on the native X chromosome. However, rex sites maintain their ability to bind large amounts of DCC even on X duplications detached from the native X, while way stations do not. These results suggest that two distinct classes of DCC-binding elements facilitate recruitment and spreading of the DCC along the X chromosome.

Links

PubMed PMC2663307 Online version:10.1128/MCB.01448-08

Keywords

Animals; Binding Sites; Caenorhabditis elegans/genetics; Chromosomal Proteins, Non-Histone/metabolism; Chromosomal Proteins, Non-Histone/physiology; Dosage Compensation, Genetic; Female; Gene Expression Regulation; Genes, Helminth; Genes, X-Linked; Nuclear Proteins/metabolism; Nuclear Proteins/physiology; Protein Transport; Regulatory Elements, Transcriptional; Transcription, Genetic; X Chromosome

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:CAPG1

involved_in

GO:0045144: meiotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:CAPG1

part_of

GO:0046536: dosage compensation complex

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00001086

C

Seeded From UniProt

complete

CAEEL:CAPG1

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:DPY26

involved_in

GO:0045144: meiotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:DPY26

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:KLE2

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00092413
WB:WBVar00250787

P

Seeded From UniProt

complete

CAEEL:SMC4

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00250831

P

Seeded From UniProt

complete

CAEEL:Q20818

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00250797

P

Seeded From UniProt

complete

CAEEL:CND1

involved_in

GO:0045144: meiotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:CND1

involved_in

GO:0000070: mitotic sister chromatid segregation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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