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PMID:19188424

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Citation

Oh, E and Thurmond, DC (2009) Munc18c depletion selectively impairs the sustained phase of insulin release. Diabetes 58:1165-74

Abstract

The Sec1/Munc18 protein Munc18c has been implicated in Syntaxin 4-mediated exocytosis events, although its purpose in exocytosis has remained elusive. Given that Syntaxin 4 functions in the second phase of glucose-stimulated insulin secretion (GSIS), we hypothesized that Munc18c would also be required and sought insight into the possible mechanism(s) using the islet beta-cell as a model system.

Links

PubMed PMC2671048 Online version:10.2337/db08-1059

Keywords

Animals; CHO Cells; Cricetinae; Cricetulus; DNA Primers; Diabetes Mellitus, Type 2/genetics; Diabetes Mellitus, Type 2/physiopathology; Exocytosis; Female; Gene Silencing; Insulin/secretion; Insulin-Secreting Cells/secretion; Islets of Langerhans/secretion; Mice; Mice, Knockout; Munc18 Proteins/deficiency; Munc18 Proteins/genetics; Polymorphism, Single Nucleotide; RNA, Messenger/genetics; Transfection; Vesicle-Associated Membrane Protein 2/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:VAMP2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P70452

F

Seeded From UniProt

complete

MOUSE:STX4

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P63044
PR:Q60770

F

Seeded From UniProt

complete

MOUSE:STXB3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

PR:P70452

F

Seeded From UniProt

complete

MOUSE:STXB3

acts_upstream_of_or_within

GO:0030073: insulin secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3573931

P

Seeded From UniProt

complete

MOUSE:STXB3

acts_upstream_of_or_within

GO:0022615: protein to membrane docking

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:STXB3

acts_upstream_of_or_within

GO:0006887: exocytosis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3573931

P

Seeded From UniProt

complete


See also

References

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