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PMID:19097904

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Citation

Lee, E, Sivan-Loukianova, E, Eberl, DF and Kernan, MJ (2008) An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia. Curr. Biol. 18:1899-906

Abstract

Conserved intraflagellar transport (IFT) particle proteins and IFT-associated motors are needed to assemble most eukaryotic cilia and flagella. Proteins in an IFT-A subcomplex are generally required for dynein-driven retrograde IFT, from the ciliary tip to the base. We describe novel structural and functional roles for IFT-A proteins in chordotonal organs, insect mechanosensory organs with cilia that are both sensory and motile.

Links

PubMed PMC2615538 Online version:10.1016/j.cub.2008.11.020

Keywords

Animals; Animals, Genetically Modified; Cilia/physiology; Cilia/ultrastructure; Drosophila/genetics; Drosophila/physiology; Drosophila/ultrastructure; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Dyneins/genetics; Dyneins/physiology; Flagella/physiology; Genes, Insect; Mechanotransduction, Cellular/genetics; Mechanotransduction, Cellular/physiology; Molecular Motor Proteins/genetics; Molecular Motor Proteins/physiology; Mutation; Sense Organs/physiology; Sense Organs/ultrastructure; TRPV Cation Channels/genetics; TRPV Cation Channels/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:EYS

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q0E8P6

involved_in

GO:0035721: intraciliary retrograde transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KRS6

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q7KTZ4

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q7KTZ4

involved_in

GO:0007605: sensory perception of sound

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KTZ4

involved_in

GO:0035721: intraciliary retrograde transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KTZ4

involved_in

GO:1905515: non-motile cilium assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8T9D3

involved_in

GO:0035721: intraciliary retrograde transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8T9D3

involved_in

GO:1905515: non-motile cilium assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9V9R6

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9VPR0

located_in

GO:0097730: non-motile cilium

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9VPR0

involved_in

GO:0007605: sensory perception of sound

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VPR0

involved_in

GO:0035721: intraciliary retrograde transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VPR0

involved_in

GO:1905515: non-motile cilium assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VSJ6

involved_in

GO:0035721: intraciliary retrograde transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VSJ6

involved_in

GO:1905515: non-motile cilium assembly

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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