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PMID:19081843

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Citation

Zhou, J, Li, W, Kamei, H and Duan, C (2008) Duplication of the IGFBP-2 gene in teleost fish: protein structure and functionality conservation and gene expression divergence. PLoS ONE 3:e3926

Abstract

Insulin-like growth factor binding protein-2 (IGFBP-2) is a secreted protein that binds and regulates IGF actions in controlling growth, development, reproduction, and aging. Elevated expression of IGFBP-2 is often associated with progression of many types of cancers.

Links

PubMed PMC2593780 Online version:10.1371/journal.pone.0003926

Keywords

Amino Acid Sequence; Animals; Body Patterning; Cell Lineage; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/metabolism; Embryonic Development; Evolution, Molecular; Fishes/genetics; Gene Duplication; Gene Expression Regulation, Developmental; Genetic Variation; Heparin/metabolism; Insulin-Like Growth Factor Binding Protein 2/chemistry; Insulin-Like Growth Factor Binding Protein 2/genetics; Integrins/metabolism; Molecular Sequence Data; Phylogeny; Protein Binding; Somatomedins/metabolism; Synteny; Zebrafish/embryology; Zebrafish/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:IBP2B

enables

GO:0005520: insulin-like growth factor binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DANRE:IBP2B

enables

GO:0031994: insulin-like growth factor I binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

DANRE:IBP2B

located_in

GO:0005576: extracellular region

ECO:0000305: curator inference used in manual assertion

GO:0031994

C

Seeded From UniProt

complete

DANRE:IBP2B

involved_in

GO:0048640: negative regulation of developmental growth

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IBP2

enables

GO:0031994: insulin-like growth factor I binding

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:IBP2

involved_in

GO:0043567: regulation of insulin-like growth factor receptor signaling pathway

ECO:0000305: curator inference used in manual assertion

GO:0031994

P

Seeded From UniProt

complete

DANRE:IBP2A

involved_in

GO:0048640: negative regulation of developmental growth

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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