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PMID:19013143

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Citation

Evans, TA, Haridas, H and Duffy, JB (2009) Kekkon5 is an extracellular regulator of BMP signaling. Dev. Biol. 326:36-46

Abstract

Precise spatial and temporal control of Drosophila Bone Morphogenetic Protein (BMP) signaling is achieved by a host of extracellular factors that modulate ligand distribution and activity. Here we describe Kekkon5 (Kek5), a transmembrane protein containing leucine-rich repeats (LRRs), as a novel regulator of BMP signaling in Drosophila. We find that loss or gain of kek5 disrupts crossvein development and alters the early profile of phosphorylated Mad and dSRF in presumptive crossvein cells. kek5 phenotypic effects closely mimic those observed with Short gastrulation (Sog), but do not completely recapitulate the effects of dominant negative BMP receptors. We further demonstrate that Kek5 is able to antagonize the BMP ligand Glass bottom boat (Gbb) and that the Kek5 LRRs are required for BMP inhibitory activity, while the Ig domain is dispensable in this context. Our identification of Kek5 as a modulator of BMP signaling supports the emerging notion that LIG proteins function as diverse regulators of cellular communication.

Links

PubMed Online version:10.1016/j.ydbio.2008.10.002

Keywords

Animals; Bone Morphogenetic Proteins/physiology; Cell Communication; Central Nervous System/embryology; Central Nervous System/growth & development; DNA-Binding Proteins/metabolism; Drosophila/embryology; Drosophila/growth & development; Drosophila/physiology; Drosophila Proteins/antagonists & inhibitors; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Membrane Proteins/genetics; Membrane Proteins/physiology; Mutation; Phosphorylation; Pupa; Signal Transduction; Transcription Factors/metabolism; Transforming Growth Factor beta/antagonists & inhibitors; Transforming Growth Factor beta/metabolism; Wing/growth & development

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q86PM1

located_in

GO:0005887: integral component of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9VWI6

involved_in

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VWI6

located_in

GO:0005887: integral component of plasma membrane

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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