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PMID:18953338

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Citation

Deddouche, S, Matt, N, Budd, A, Mueller, S, Kemp, C, Galiana-Arnoux, D, Dostert, C, Antoniewski, C, Hoffmann, JA and Imler, JL (2008) The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila. Nat. Immunol. 9:1425-32

Abstract

Drosophila, like other invertebrates and plants, relies mainly on RNA interference for its defense against viruses. In flies, viral infection also triggers the expression of many genes. One of the genes induced, Vago, encodes a 18-kilodalton cysteine-rich polypeptide. Here we provide genetic evidence that the Vago gene product controlled viral load in the fat body after infection with drosophila C virus. Induction of Vago was dependent on the helicase Dicer-2. Dicer-2 belongs to the same DExD/H-box helicase family as do the RIG-I-like receptors, which sense viral infection and mediate interferon induction in mammals. We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses.

Links

PubMed Online version:10.1038/ni.1664

Keywords

Animals; Animals, Genetically Modified; Drosophila/immunology; Drosophila/virology; Drosophila Proteins/genetics; Drosophila Proteins/immunology; Drosophila Proteins/metabolism; Electrophoresis, Polyacrylamide Gel; Fat Body/immunology; Fat Body/virology; Gene Expression Regulation/immunology; Humans; Phylogeny; RNA Helicases/genetics; RNA Helicases/immunology; RNA Helicases/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Ribonuclease III; Sequence Homology, Amino Acid; Transcription, Genetic; Virus Diseases/immunology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:A0A0B4LFK8

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:A1ZAW0

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3V4

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3V5

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3V6

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3V7

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3V8

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3V9

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3W0

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q2Q3W1

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8MYS7

involved_in

GO:0051607: defense response to virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95YG3

involved_in

GO:0009597: detection of virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VZ35

involved_in

GO:0051607: defense response to virus

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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