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PMID:18950512

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Citation

Eid, JP, Arias, AM, Robertson, H, Hime, GR and Dziadek, M (2008) The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning. BMC Dev. Biol. 8:104

Abstract

Mammalian STIM1 and STIM2 and the single Drosophila homologue dSTIM have been identified as key regulators of store-operated Ca2+ entry in cells. STIM proteins function both as molecular sensors of Ca2+concentration in the endoplasmic reticulum (ER) and the molecular triggers that activate SOC channels in the plasma membrane. Ca2+ is a crucial intracellular messenger utilised in many cellular processes, and regulators of Ca2+ homeostasis in the ER and cytosol are likely to play important roles in developmental processes. STIM protein expression is altered in several tumour types but the role of these proteins in developmental signalling pathways has not been thoroughly examined.

Links

PubMed PMC2584103 Online version:10.1186/1471-213X-8-104

Keywords

Animals; Animals, Genetically Modified; Body Patterning/genetics; Calcium/metabolism; Cell Differentiation; Drosophila/embryology; Drosophila/genetics; Drosophila/growth & development; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Embryo, Nonmammalian/metabolism; Endoplasmic Reticulum/metabolism; In Situ Hybridization, Fluorescence; Membrane Proteins/genetics; Membrane Proteins/metabolism; Membrane Proteins/physiology; RNA Interference; Receptors, Notch/genetics; Receptors, Notch/metabolism; Signal Transduction; Wnt1 Protein/genetics; Wnt1 Protein/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:STIM

involved_in

GO:0022416: chaeta development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:STIM

involved_in

GO:0007476: imaginal disc-derived wing morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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