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PMID:18930438

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Citation

Racioppi, L and Means, AR (2008) Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient traveller. Trends Immunol. 29:600-7

Abstract

Ca(2+) is a pivotal second messenger controlling the activation of lymphocytes. Crucial events in the social life of immunocytes are regulated by the calcium/calmodulin complex (Ca(2+)/CaM), which controls the activation status of many enzymes, including the Ca(2+)/CaM-dependent Ser-Thr kinases (CaMK) I, II and IV. Although CaMKI and CaMKII are expressed ubiquitously, CaMKIV is found predominately in cells of the nervous and immune systems. To be active, CaMKIV requires binding of Ca(2+)/CaM and phosphorylation by CaMKKalpha or beta. The requirement of two CaM kinases in the same signalling pathway led to the concept of a CaM kinase cascade. In this review, we focus on the roles of CaMKK and CaMKIV cascades in immune and inflammatory responses.

Links

PubMed Online version:10.1016/j.it.2008.08.005

Keywords

Animals; Calcium/metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 4/chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 4/genetics; Calcium-Calmodulin-Dependent Protein Kinase Type 4/metabolism; Immune System/enzymology; Immune System/immunology; Inflammation/enzymology; Inflammation/genetics; Inflammation/immunology; Signal Transduction/immunology; T-Lymphocytes/cytology; T-Lymphocytes/immunology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:KCC4

involved_in

GO:0045670: regulation of osteoclast differentiation

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:KCC4

involved_in

GO:0033081: regulation of T cell differentiation in thymus

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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