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PMID:18809578

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Citation

Tsang, CW, Fedchyshyn, M, Harrison, J, Xie, H, Xue, J, Robinson, PJ, Wang, LY and Trimble, WS (2008) Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission. Mol. Cell. Biol. 28:7012-29

Abstract

The septin family of GTPases, first identified for their roles in cell division, are also expressed in postmitotic tissues. SEPT3 (G-septin) and SEPT5 (CDCrel-1) are highly expressed in neurons, enriched in presynaptic terminals, and associated with synaptic vesicles. These characteristics suggest that SEPT3 or SEPT5 might be important for synapse formation, maturation, or synaptic vesicle traffic. Since Sept5(-/-) mice do not show any overt neurological phenotypes, we generated Sept3(-/-) and Sept3(-/-) Sept5(-/-) mice and found that SEPT3 and SEPT5 are not essential for development, fertility, or viability. Changes in the expression of septins were noted in the absence of SEPT3, SEPT5, and both septins. SEPT5 association with other septins in brain tissue was unaffected by the removal of SEPT3. No abnormalities were observed in the gross morphology and synapses of the hippocampus. Similarly, axon development and synapse formation were unaffected in vitro. In cultured hippocampal neurons, the size of the recycling synaptic vesicle pool was unaltered in the absence of SEPT3. Furthermore, synaptic transmission at two different central synapses was not significantly affected in Sept3(-/-) Sept5(-/-) mice. These results indicate that SEPT3 and SEPT5 are dispensable for neuronal development as well as for synaptic vesicle fusion and recycling.

Links

PubMed PMC2593370 Online version:10.1128/MCB.00035-08

Keywords

Animals; Brain Chemistry; Cell Cycle Proteins/pharmacokinetics; GTP-Binding Proteins/physiology; Hippocampus/cytology; Mice; Mice, Knockout; Nerve Tissue Proteins/physiology; Neurogenesis; Neurons/chemistry; Neurons/cytology; Neurons/physiology; Septins; Synaptic Transmission; Synaptic Vesicles/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SEPT7

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT7

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT4

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT4

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT2

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT9

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT9

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEP11

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEP11

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT8

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT8

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT6

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT6

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:Q9Z2Q6

F

Seeded From UniProt

complete

MOUSE:SEPT3

located_in

GO:0098793: presynapse

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT3

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT5

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:O55131
UniProtKB:P28661
UniProtKB:P42208
UniProtKB:Q80UG5
UniProtKB:Q8C1B7
UniProtKB:Q8CHH9
UniProtKB:Q9R1T4
UniProtKB:Q9Z1S5

F

Seeded From UniProt

complete

MOUSE:SEPT5

located_in

GO:0098793: presynapse

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT5

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:SEPT2

part_of

GO:0031105: septin complex

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

Notes

See also

References

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