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PMID:18805097

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Citation

Del Bene, F, Wehman, AM, Link, BA and Baier, H (2008) Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Cell 134:1055-65

Abstract

The different cell types in the central nervous system develop from a common pool of progenitor cells. The nuclei of progenitors move between the apical and basal surfaces of the neuroepithelium in phase with their cell cycle, a process termed interkinetic nuclear migration (INM). In the retina of zebrafish mikre oko (mok) mutants, in which the motor protein Dynactin-1 is disrupted, interkinetic nuclei migrate more rapidly and deeply to the basal side and more slowly to the apical side. We found that Notch signaling is predominantly activated on the apical side in both mutants and wild-type. Mutant progenitors are, thus, less exposed to Notch and exit the cell cycle prematurely. This leads to an overproduction of early-born retinal ganglion cells (RGCs) at the expense of later-born interneurons and glia. Our data indicate that the function of INM is to balance the exposure of progenitor nuclei to neurogenic versus proliferative signals.

Links

PubMed PMC2628487 Online version:10.1016/j.cell.2008.07.017

Keywords

Animals; Body Patterning; Cell Cycle; Cell Differentiation; Cell Nucleus/metabolism; Embryo, Nonmammalian/metabolism; Gene Expression Regulation, Developmental; Microtubule-Associated Proteins/genetics; Mutation; Neuroepithelial Cells/cytology; Neuroepithelial Cells/metabolism; Organogenesis; Receptors, Notch/metabolism; Retina/cytology; Retina/embryology; Retinal Ganglion Cells/metabolism; Stem Cells/cytology; Stem Cells/metabolism; Zebrafish; Zebrafish Proteins/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DANRE:A0A286YA27

involved_in

GO:0007097: nuclear migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A286YA27

involved_in

GO:0010842: retina layer formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A286YA27

involved_in

GO:0010842: retina layer formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete

DANRE:A0A286YA27

involved_in

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A286YA27

involved_in

GO:0060042: retina morphogenesis in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A2R8RP20

involved_in

GO:0007097: nuclear migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A2R8RP20

involved_in

GO:0010842: retina layer formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A2R8RP20

involved_in

GO:0010842: retina layer formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete

DANRE:A0A2R8RP20

involved_in

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:A0A2R8RP20

involved_in

GO:0060042: retina morphogenesis in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:F1R0W9

involved_in

GO:0007097: nuclear migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:F1R0W9

involved_in

GO:0010842: retina layer formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:F1R0W9

involved_in

GO:0010842: retina layer formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete

DANRE:F1R0W9

involved_in

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:F1R0W9

involved_in

GO:0060042: retina morphogenesis in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q07DR3

involved_in

GO:0007097: nuclear migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q07DR3

involved_in

GO:0010842: retina layer formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q07DR3

involved_in

GO:0010842: retina layer formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete

DANRE:Q07DR3

involved_in

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q07DR3

involved_in

GO:0060042: retina morphogenesis in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q7T2F8

involved_in

GO:0007097: nuclear migration

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q7T2F8

involved_in

GO:0010842: retina layer formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q7T2F8

involved_in

GO:0010842: retina layer formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete

DANRE:Q7T2F8

involved_in

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:Q7T2F8

involved_in

GO:0060042: retina morphogenesis in camera-type eye

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete

DANRE:ATOH7

involved_in

GO:0010842: retina layer formation

ECO:0000315: mutant phenotype evidence used in manual assertion

ZFIN:ZDB-GENO-090608-3

P

Seeded From UniProt

complete

DANRE:ATOH7

involved_in

GO:0010842: retina layer formation

ECO:0000316: genetic interaction evidence used in manual assertion

ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete

DANRE:E7F1E0

GO:0040023: establishment of nucleus localization

IMP: Inferred from Mutant Phenotype: ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete


DANRE:E7F1E0

GO:0048663: neuron fate commitment

IMP: Inferred from Mutant Phenotype: ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete


DANRE:E7F1E0

GO:0060042: retina morphogenesis in camera-type eye

IMP: Inferred from Mutant Phenotype: ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete


DANRE:E7F1E0

GO:0010842: retina layer formation

IMP: Inferred from Mutant Phenotype: ZFIN:ZDB-GENO-090312-5

P

Seeded From UniProt

complete


DANRE:E7F1E0

GO:0010842: retina layer formation

IGI: Inferred from Genetic Interaction: ZFIN:ZDB-GENO-090608-5

P

Seeded From UniProt

complete



See also

References

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