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PMID:18802472

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Citation

Grieder, NC, Caussinus, E, Parker, DS, Cadigan, K, Affolter, M and Luschnig, S (2008) gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster. PLoS ONE 3:e3241

Abstract

There is increasing evidence that tissue-specific modifications of basic cellular functions play an important role in development and disease. To identify the functions of COPI coatomer-mediated membrane trafficking in Drosophila development, we were aiming to create loss-of-function mutations in the gammaCOP gene, which encodes a subunit of the COPI coatomer complex.

Links

PubMed PMC2532760 Online version:10.1371/journal.pone.0003241

Keywords

Alleles; Animals; Coatomer Protein/genetics; Coatomer Protein/metabolism; Coatomer Protein/physiology; Crosses, Genetic; Drosophila melanogaster/metabolism; Epithelium/metabolism; Gene Deletion; Gene Expression Regulation; Models, Biological; Models, Genetic; Mutation; Phenotype; Trachea/pathology; Transgenes

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:COPG

involved_in

GO:0007424: open tracheal system development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0009306: protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0008362: chitin-based embryonic cuticle biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

located_in

GO:0005794: Golgi apparatus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0035149: lumen formation, open tracheal system

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0035147: branch fusion, open tracheal system

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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