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PMID:18758451

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Citation

Zheng, Y, Wildonger, J, Ye, B, Zhang, Y, Kita, A, Younger, SH, Zimmerman, S, Jan, LY and Jan, YN (2008) Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. Nat. Cell Biol. 10:1172-80

Abstract

Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons. Changes in organelle distribution within the dendritic arbors of dynein mutant neurons correlate with a proximal shift in dendritic branch position. Dynein is also necessary for the dendrite-specific localization of Golgi outposts and the ion channel Pickpocket. Axonal microtubules are normally oriented uniformly plus-end-distal; however, without dynein, axons contain both plus- and minus-end distal microtubules. These data suggest that dynein is required for the distinguishing properties of the axon and dendrites: without dynein, dendritic organelles and proteins enter the axon and the axonal microtubules are no longer uniform in polarity.

Links

PubMed PMC2588425 Online version:10.1038/ncb1777

Keywords

Animals; Axons/metabolism; Biological Transport; Cell Polarity; Dendrites/metabolism; Drosophila Proteins/metabolism; Drosophila melanogaster/cytology; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Dyneins/metabolism; Endosomes/metabolism; Genes, Insect; Golgi Apparatus/metabolism; Green Fluorescent Proteins/metabolism; Male; Microtubules/metabolism; Mutation/genetics; Recombinant Fusion Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:DYIN

involved_in

GO:0000226: microtubule cytoskeleton organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DYIN

involved_in

GO:0008088: axo-dendritic transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:DYIN

involved_in

GO:0007018: microtubule-based movement

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:LIS1

involved_in

GO:0048814: regulation of dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IR93

involved_in

GO:0000226: microtubule cytoskeleton organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IR93

involved_in

GO:0008088: axo-dendritic transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IR93

involved_in

GO:0007018: microtubule-based movement

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8IR93

involved_in

GO:0048814: regulation of dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VZ20

involved_in

GO:0000226: microtubule cytoskeleton organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VZ20

involved_in

GO:0008088: axo-dendritic transport

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VZ20

involved_in

GO:0007018: microtubule-based movement

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VZ20

involved_in

GO:0048814: regulation of dendrite morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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