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PMID:18687588

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Citation

Zheng, BS, Rönnberg, E, Viitanen, L, Salminen, TA, Lundgren, K, Moritz, T and Edqvist, J (2008) Arabidopsis sterol carrier protein-2 is required for normal development of seeds and seedlings. J. Exp. Bot. 59:3485-99

Abstract

The Arabidopsis thaliana sterol carrier protein-2 (AtSCP2) is a small, basic and peroxisomal protein that in vitro enhances the transfer of lipids between membranes. AtSCP2 and all other plant SCP-2 that have been identified are single-domain polypeptides, whereas in many other eukaryotes SCP-2 domains are expressed in the terminus of multidomain polypeptides. The AtSCP2 transcript is expressed in all analysed tissues and developmental stages, with the highest levels in floral tissues and in maturing seeds. The expression of AtSCP2 is highly correlated with the multifunctional protein-2 (MFP2) involved in beta-oxidation. A. thaliana Atscp2-1 plants deficient in AtSCP2 show altered seed morphology, a delayed germination, and are dependent on an exogenous carbon source to avoid a delayed seedling establishment. Metabolomic investigations revealed 110 variables (putative metabolites) that differed in relative concentration between Atscp2-1 and normal A. thaliana wild-type seedlings. Microarray analysis revealed that many genes whose expression is altered in mutants with a deficiency in the glyoxylate pathway, also have a changed expression level in Atscp2-1.

Links

PubMed PMC2529247 Online version:10.1093/jxb/ern201

Keywords

Arabidopsis/chemistry; Arabidopsis/genetics; Arabidopsis/growth & development; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Carrier Proteins/chemistry; Carrier Proteins/genetics; Carrier Proteins/metabolism; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Germination; Models, Molecular; Mutagenesis, Insertional; Seedling/chemistry; Seedling/genetics; Seedling/growth & development; Seedling/metabolism; Seeds/chemistry; Seeds/genetics; Seeds/growth & development; Seeds/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:SCP2

involved_in

GO:0009744: response to sucrose

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:SCP2

involved_in

GO:0009646: response to absence of light

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:SCP2

involved_in

GO:0048317: seed morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:SCP2

acts_upstream_of_or_within

GO:0032365: intracellular lipid transport

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

ARATH:SCP2

acts_upstream_of_or_within

GO:0006635: fatty acid beta-oxidation

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:SCP2

acts_upstream_of_or_within

GO:0009845: seed germination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:SCP2

acts_upstream_of_or_within

GO:0046487: glyoxylate metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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