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PMID:18674914

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Citation

Reiner, DJ, Ailion, M, Thomas, JH and Meyer, BJ (2008) C. elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-beta signaling. Curr. Biol. 18:1101-9

Abstract

Different environmental stimuli, including exposure to dauer pheromone, food deprivation, and high temperature, can induce C. elegans larvae to enter the dauer stage, a developmentally arrested diapause state. Although molecular and cellular pathways responsible for detecting dauer pheromone and temperature have been defined in part, other sensory inputs are poorly understood, as are the mechanisms by which these diverse sensory inputs are integrated to achieve a consistent developmental outcome.

Links

PubMed Online version:10.1016/j.cub.2008.06.060

Keywords

Adaptation, Biological; Animals; Caenorhabditis elegans/enzymology; Caenorhabditis elegans/genetics; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/metabolism; Caenorhabditis elegans Proteins/physiology; Desert Climate; Feeding Behavior; Ligands; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Phenotype; Pheromones/metabolism; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Protein-Tyrosine Kinases/physiology; Signal Transduction; Smad Proteins/genetics; Smad Proteins/metabolism; Transforming Growth Factor beta/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:SMA5

involved_in

GO:0040024: dauer larval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000903

P

Seeded From UniProt

complete

CAEEL:G5ECA8

involved_in

GO:0040024: dauer larval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000903

P

Seeded From UniProt

complete

CAEEL:SOC1

involved_in

GO:0040024: dauer larval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000903

P

Seeded From UniProt

complete

CAEEL:SCD2

involved_in

GO:0040024: dauer larval development

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00000903

P

Seeded From UniProt

complete


See also

References

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