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PMID:18478054

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Citation

Suh, JM, Stenesen, D, Peters, JM, Inoue, A, Cade, A and Graff, JM (2008) An RGS-containing sorting nexin controls Drosophila lifespan. PLoS ONE 3:e2152

Abstract

The pursuit of eternal youth has existed for centuries and recent data indicate that fat-storing tissues control lifespan. In a D. melanogaster fat body insertional mutagenic enhancer trap screen designed to isolate genes that control longevity, we identified a regulator of G protein signaling (RGS) domain containing sorting nexin, termed snazarus (sorting nexin lazarus, snz). Flies with insertions into the 5' UTR of snz live up to twice as long as controls. Transgenic expression of UAS-Snz from the snz Gal4 enhancer trap insertion, active in fat metabolic tissues, rescued lifespan extension. Further, the lifespan extension of snz mutants was independent of endosymbiont, e.g., Wolbachia, effects. Notably, old snz mutant flies remain active and fertile indicating that snz mutants have prolonged youthfulness, a goal of aging research. Since mammals have snz-related genes, it is possible that the functions of the snz family may be conserved to humans.

Links

PubMed PMC2359856 Online version:10.1371/journal.pone.0002152

Keywords

5' Untranslated Regions; Animals; Animals, Genetically Modified; Carrier Proteins/chemistry; Carrier Proteins/physiology; Drosophila/genetics; Drosophila/physiology; Fat Body/physiology; Larva/physiology; Longevity; Mutation; Oligopeptides/chemistry; Sorting Nexins; Vesicular Transport Proteins/chemistry; Vesicular Transport Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q8T4E8

enables

GO:0005543: phospholipid binding

ECO:0000255: match to sequence model evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q8T4E8

located_in

GO:0016020: membrane

ECO:0000255: match to sequence model evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q8T4E8

involved_in

GO:0008340: determination of adult lifespan

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W3N0

enables

GO:0005543: phospholipid binding

ECO:0000255: match to sequence model evidence used in manual assertion

F

Seeded From UniProt

complete

DROME:Q9W3N0

located_in

GO:0016020: membrane

ECO:0000255: match to sequence model evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q9W3N0

involved_in

GO:0008340: determination of adult lifespan

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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