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PMID:18471277

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Citation

Pispa, J, Palmén, S, Holmberg, CI and Jäntti, J (2008) C. elegans dss-1 is functionally conserved and required for oogenesis and larval growth. BMC Dev. Biol. 8:51

Abstract

Dss1 (or Rpn15) is a recently identified subunit of the 26S proteasome regulatory particle. In addition to its function in the protein degradation machinery, it has been linked to BRCA2 (breast cancer susceptibility gene 2 product) and homologous DNA recombination, mRNA export, and exocytosis. While the fungal orthologues of Dss1 are not essential for viability, the significance of Dss1 in metazoans has remained unknown due to a lack of knockout animal models.

Links

PubMed PMC2409312 Online version:10.1186/1471-213X-8-51

Keywords

Animals; Base Sequence; Caenorhabditis elegans/genetics; Caenorhabditis elegans/growth & development; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/physiology; DNA Primers/genetics; Female; Fertility/genetics; Fertility/physiology; Gene Expression Regulation, Developmental; Gene Targeting; Genes, Helminth; Larva/growth & development; Male; Mutation; Oogenesis/genetics; Oogenesis/physiology; Phenotype; Proteasome Endopeptidase Complex/genetics; Proteasome Endopeptidase Complex/physiology; RNA Interference; RNA, Helminth/genetics; RNA, Helminth/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:DSS1

involved_in

GO:0002119: nematode larval development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBRNAi00077512

P

Seeded From UniProt

complete

CAEEL:DSS1

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:DSS1

located_in

GO:0005737: cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0031398: positive regulation of protein ubiquitination

ECO:0000316: genetic interaction evidence used in manual assertion

SGD:S000007235

P

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0009792: embryo development ending in birth or egg hatching

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBRNAi00077512

P

Seeded From UniProt

complete

CAEEL:DSS1

part_of

GO:0008541: proteasome regulatory particle, lid subcomplex

ECO:0000250: sequence similarity evidence used in manual assertion

UniProtKB:O94742

C

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0050892: intestinal absorption

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBRNAi00077514
WB:WBVar00249418

P

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0060429: epithelium development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBRNAi00077512

P

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0048477: oogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBRNAi00077512
WB:WBVar00249418

P

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0045927: positive regulation of growth

ECO:0000316: genetic interaction evidence used in manual assertion

SGD:S000007235

P

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0040025: vulval development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBRNAi00077514
WB:WBVar00249418

P

Seeded From UniProt

complete

CAEEL:DSS1

involved_in

GO:0040018: positive regulation of multicellular organism growth

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00249418

P

Seeded From UniProt

complete


See also

References

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