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PMID:18423434

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Citation

Pham, H, Yu, H and Laski, FA (2008) Cofilin/ADF is required for retinal elongation and morphogenesis of the Drosophila rhabdomere. Dev. Biol. 318:82-91

Abstract

Drosophila photoreceptors undergo marked changes in their morphology during pupal development. These changes include a five-fold elongation of the retinal cell body and the morphogenesis of the rhabdomere, the light sensing structure of the cell. Here we show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for both of these processes. In tsr mutants, the retina is shorter than normal, the result of a lack of retinal elongation. In addition, in a strong tsr mutant, the rhabdomere structure is disorganized and the microvilli are short and occasionally unraveled. In an intermediate tsr mutant, the rhabdomeres are not disorganized but have a wider than normal structure. The adherens junctions connecting photoreceptor cells to each other are also found to be wider than normal. We propose, and provide data supporting, that these wide rhabdomeres and adherens junctions are secondary events caused by the inhibition of retinal elongation. These results provide insight into the functions of the actin cytoskeleton during morphogenesis of the Drosophila eye.

Links

PubMed PMC2713181 Online version:10.1016/j.ydbio.2008.03.006

Keywords

Actin Depolymerizing Factors/genetics; Actin Depolymerizing Factors/metabolism; Adherens Junctions/metabolism; Animals; Cytoskeleton/metabolism; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila melanogaster/anatomy & histology; Drosophila melanogaster/embryology; Female; Male; Microfilament Proteins/genetics; Microfilament Proteins/metabolism; Morphogenesis; Mutation; Phenotype; Photoreceptor Cells, Invertebrate/anatomy & histology; Photoreceptor Cells, Invertebrate/embryology; Photoreceptor Cells, Invertebrate/metabolism; Retina/cytology; Retina/embryology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:CADF

involved_in

GO:0001745: compound eye morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:CADF

involved_in

GO:0042052: rhabdomere development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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