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PMID:18398480

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Citation

Jayaram, SA, Senti, KA, Tiklová, K, Tsarouhas, V, Hemphälä, J and Samakovlis, C (2008) COPI vesicle transport is a common requirement for tube expansion in Drosophila. PLoS ONE 3:e1964

Abstract

Tube expansion defects like stenoses and atresias cause devastating human diseases. Luminal expansion during organogenesis begins to be elucidated in several systems but we still lack a mechanistic view of the process in many organs. The Drosophila tracheal respiratory system provides an amenable model to study tube size regulation. In the trachea, COPII anterograde transport of luminal proteins is required for extracellular matrix assembly and the concurrent tube expansion.

Links

PubMed PMC2276865 Online version:10.1371/journal.pone.0001964

Keywords

Animals; Biological Transport; Coat Protein Complex I/metabolism; Coatomer Protein/metabolism; Drosophila/metabolism; Drosophila Proteins/metabolism; Endoplasmic Reticulum/metabolism; Extracellular Matrix/metabolism; Golgi Apparatus/metabolism; Models, Biological; Mutation; Phenotype; Respiratory System; Trachea/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:Q7K7G0

involved_in

GO:0007436: larval salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7K7G0

involved_in

GO:0009306: protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7K7G0

involved_in

GO:0035158: regulation of tube diameter, open tracheal system

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0030198: extracellular matrix organization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

located_in

GO:0005801: cis-Golgi network

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:COPG

located_in

GO:0005783: endoplasmic reticulum

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0007436: larval salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0009306: protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:COPG

involved_in

GO:0035158: regulation of tube diameter, open tracheal system

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U8A9

involved_in

GO:0007436: larval salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U8A9

involved_in

GO:0009306: protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9U8A9

involved_in

GO:0035158: regulation of tube diameter, open tracheal system

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W555

involved_in

GO:0007436: larval salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W555

involved_in

GO:0009306: protein secretion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9W555

involved_in

GO:0035158: regulation of tube diameter, open tracheal system

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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