PMID:18356246

Citation	Suzuki, A, Sekiya, S, Büscher, D, Izpisúa Belmonte, JC and Taniguchi, H (2008) Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression. Development 135:1589-95
Abstract	Although the T-box family of transcription factors function in many different tissues, their role in liver development is unknown. Here we show that Tbx3, the T-box gene that is mutated in human ulnar-mammary syndrome, is specifically expressed in multipotent hepatic progenitor cells, ;hepatoblasts', isolated from the developing mouse liver. Tbx3-deficient hepatoblasts presented severe defects in proliferation as well as uncontrollable hepatobiliary lineage segregation, including the promotion of cholangiocyte (biliary epithelial cell) differentiation, which thereby caused abnormal liver development. Deletion of Tbx3 resulted in the increased expression of the tumor suppressor p19(ARF) (Cdkn2a), which in turn induced a growth arrest in hepatoblasts and activated a program of cholangiocyte differentiation. Thus, Tbx3 plays a crucial role in controlling hepatoblast proliferation and cell-fate determination by suppressing p19(ARF) expression and thereby promoting liver organogenesis.
Links	PubMed Online version:10.1242/dev.016634
Keywords	Animals; Cell Differentiation/physiology; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p16/biosynthesis; Liver/cytology; Liver/embryology; Mice; Multipotent Stem Cells/cytology; Multipotent Stem Cells/physiology; T-Box Domain Proteins/physiology
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
MOUSE:TBX3	involved_in	GO:0061017: hepatoblast differentiation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:3769504	P		Seeded From UniProt	complete
MOUSE:TBX3	involved_in	GO:0019827: stem cell population maintenance	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:3769504	P		Seeded From UniProt	complete
MOUSE:TBX3	involved_in	GO:2000648: positive regulation of stem cell proliferation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:3769504	P		Seeded From UniProt	complete
MOUSE:TBX3	involved_in	GO:2000737: negative regulation of stem cell differentiation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:3769504	P		Seeded From UniProt	complete
MOUSE:TBX3	involved_in	GO:0072089: stem cell proliferation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:3769504	P		Seeded From UniProt	complete
MOUSE:TBX3	involved_in	GO:0030857: negative regulation of epithelial cell differentiation	ECO:0000315: mutant phenotype evidence used in manual assertion	MGI:MGI:3769504	P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.