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PMID:18314420

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Citation

Bouzakri, K, Austin, R, Rune, A, Lassman, ME, Garcia-Roves, PM, Berger, JP, Krook, A, Chibalin, AV, Zhang, BB and Zierath, JR (2008) Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle. Diabetes 57:1508-16

Abstract

Malonyl coenzyme A (CoA) decarboxylase (MCD) is a key enzyme responsible for malonyl-CoA turnover and functions in the control of the balance between lipid and glucose metabolism. We utilized RNA interference (siRNA)-based gene silencing to determine the direct role of MCD on metabolic responses in primary human skeletal muscle.

Links

PubMed Online version:10.2337/db07-0583

Keywords

Acetyl Coenzyme A/metabolism; Biopsy; Carboxy-Lyases/genetics; Carboxy-Lyases/metabolism; Ceramides/metabolism; Coenzyme A/metabolism; Diglycerides/metabolism; Fatty Acids/metabolism; Gene Silencing; Glucose/metabolism; Humans; Kinetics; Lipids/physiology; Muscle Fibers, Skeletal/enzymology; Muscle, Skeletal/enzymology; RNA, Messenger/genetics; RNA, Small Interfering/genetics; Transfection

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:DCMC

involved_in

GO:0046321: positive regulation of fatty acid oxidation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(CHEBI:15756)

Seeded From UniProt

complete

HUMAN:DCMC

involved_in

GO:0010906: regulation of glucose metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DCMC

involved_in

GO:0046321: positive regulation of fatty acid oxidation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

has_input:(CHEBI:15756)

Seeded From UniProt

complete

See also

References

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