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PMID:18295597

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Citation

O'Farrell, F and Kylsten, P (2008) Drosophila Anillin is unequally required during asymmetric cell divisions of the PNS. Biochem. Biophys. Res. Commun. 369:407-13

Abstract

During Drosophila embryogenesis, timely and orderly asymmetric cell divisions ensure the correct number of each cell type that make up the sensory organs of the larval PNS. We report a role of scraps, Drosophila Anillin, during these divisions. Anillin, a constitutive member of the contractile ring is essential for cytokinesis in Drosophila and vertebrates. During embryogenesis we find that zygotically transcribed scraps is required specifically for the unequal cell divisions, those in which cytokinesis occurs in an "off-centred" manner, of the pIIb and pIIIb neuronal precursor cells, but not the equal cell divisions of the lineage related precursor cells. Complementation and genetic rescue studies demonstrate this effect results from zygotic scraps and leads to polyploidy, ectopic mitosis, and loss of the neuronal precursor daughter cells. The net result of which is the formation of incomplete sense organs and embryonic lethality.

Links

PubMed Online version:10.1016/j.bbrc.2008.02.060

Keywords

Animals; Cell Division/physiology; Cells, Cultured; Contractile Proteins/metabolism; Cytokinesis/physiology; Drosophila melanogaster/embryology; Drosophila melanogaster/physiology; Embryonic Development/physiology; Peripheral Nerves/cytology; Peripheral Nerves/embryology; Peripheral Nerves/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:ANLN

involved_in

GO:0007423: sensory organ development

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:ANLN

involved_in

GO:0008356: asymmetric cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:ANLN

involved_in

GO:0045035: sensory organ precursor cell division

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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