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PMID:1820020

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Citation

von Deimling, OH, Gröning, J and Gaa, A (1991) Genetic and biochemical characterization of a new chymotrypsin isozyme of the house mouse, CTRA-1. Biochem. Genet. 29:545-57

Abstract

Genetic variation of a codominantly inherited pancreas protease, designated CTRA-1, was discovered in the house mouse by isoelectric focusing in polyacrylamide gels. Phenotype CTRA-1A was found in MOLH/Fre and in the majority of common laboratory mouse strains. Phenotype CTRA-1B was found in PWD/Ph. It was characterized by the absence of a corresponding protease band. A third phenotype, CTRA-1C, was observed in IS/Cam and a fourth phenotype, CTRA-1D, was detected in SEG/1. CTRA-1 was found only in the pancreas and may represent the A form of chymotrypsin. The enzyme was shown to be controlled by the presumed structural locus Ctra-1 located on chromosome 8. From two backcross series, including a total of 274 animals, the gene order (Es-1, Es-9)-3.9 +/- 1.7%-Got-2-3.9 +/- 1.7%-(Es-2, Es-7, Es-23)-0.7 +/- 0.5%- Ctra-1-6.3 +/- 2.2%-Prt-2 was established.

Links

PubMed

Keywords

Animals; Chromosome Mapping; Chymotrypsin/genetics; Chymotrypsin/isolation & purification; Chymotrypsin/metabolism; Crosses, Genetic; Female; Genes; Genetic Markers; Isoelectric Focusing; Isoenzymes/genetics; Isoenzymes/isolation & purification; Isoenzymes/metabolism; Male; Mice/genetics; Mice/metabolism; Mice, Inbred Strains/genetics; Mice, Inbred Strains/metabolism; Pancreas/enzymology; Phenotype; Species Specificity; Substrate Specificity

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


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References

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