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PMID:18178669

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Citation

Peremyslov, VV, Prokhnevsky, AI, Avisar, D and Dolja, VV (2008) Two class XI myosins function in organelle trafficking and root hair development in Arabidopsis. Plant Physiol. 146:1109-16

Abstract

Multigene families encoding class XI myosins are conserved in higher plants, however, little information is available on specific functions of these ubiquitous molecular motors. We isolated gene knockout mutants for all 13 class XI myosins present in Arabidopsis (Arabidopsis thaliana) genome. Inactivation of 11 myosin genes resulted in no discernible phenotypes under the normal growth conditions. In contrast, the knockouts of the remaining two myosin genes, XI-2 (formerly MYA2) and XI-K, exhibited similar defects in root hair elongation suggesting that the myosin-driven motility plays a significant role in a polar tip growth. Strikingly, inactivation of each of these myosins also reduced trafficking of Golgi stacks, peroxisomes, and mitochondria in root hairs and in leaf epidermal cells. These results indicate that myosins XI-K and XI-2 play major and overlapping roles in the cell dynamics in Arabidopsis and highlight the redundant nature of myosin function in plants.

Links

PubMed PMC2259062 Online version:10.1104/pp.107.113654

Keywords

Arabidopsis/growth & development; Arabidopsis/metabolism; Arabidopsis/physiology; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Homozygote; Movement/physiology; Mutagenesis, Insertional; Myosin Heavy Chains/genetics; Myosin Heavy Chains/metabolism; Myosins/genetics; Myosins/metabolism; Organelles/physiology; Plant Leaves/metabolism; Plant Leaves/physiology; Plant Roots/growth & development; Plant Roots/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ARATH:MYO17

acts_upstream_of_or_within

GO:0051646: mitochondrion localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:MYO17

acts_upstream_of_or_within

GO:0051645: Golgi localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:MYO17

acts_upstream_of_or_within

GO:0060151: peroxisome localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:F4K7C5

acts_upstream_of_or_within

GO:0051646: mitochondrion localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:F4K7C5

acts_upstream_of_or_within

GO:0051645: Golgi localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:F4K7C5

acts_upstream_of_or_within

GO:0048767: root hair elongation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

ARATH:F4K7C5

acts_upstream_of_or_within

GO:0060151: peroxisome localization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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