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PMID:18077144

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Citation

Bickel, D, Shah, R, Gesualdi, SC and Haerry, TE Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members. Mech. Dev. 125:117-29

Abstract

Follistatin (FS) is one of several secreted proteins that modulate the activity of TGF-beta family members during development. The structural and functional analysis of Drosophila Follistatin (dFS) reveals important differences between dFS and its vertebrate orthologues: it is larger, more positively charged, and proteolytically processed. dFS primarily inhibits signaling of Drosophila Activin (dACT) but can also inhibit other ligands like Decapentaplegic (DPP). In contrast, the presence of dFS enhances signaling of the Activin-like protein Dawdle (DAW), indicating that dFS exhibits a dual function in promoting and inhibiting signaling of TGF-beta ligands. In addition, FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate FS proteins. Since two PiggyBac insertions in dfs are not lethal, it appears that the function of dFS is non-essential or functionally redundant.

Links

PubMed PMC2278114 Online version:10.1016/j.mod.2007.09.013

Keywords

Animals; Base Sequence; DNA Primers; Drosophila; Follistatin/chemistry; Follistatin/genetics; Follistatin/metabolism; Hydrolysis; Immunohistochemistry; In Situ Hybridization; Ligands; Phenotype; Protein Binding; Protein Conformation; Transforming Growth Factor beta/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:INHB

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

FB:FBgn0259878

F

Seeded From UniProt

complete

DROME:Q86NV3

involved_in

GO:0030514: negative regulation of BMP signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0000490

P

Seeded From UniProt

complete

DROME:Q86NV3

involved_in

GO:0032927: positive regulation of activin receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0031461

P

Seeded From UniProt

complete

DROME:Q86NV3

involved_in

GO:0032926: negative regulation of activin receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0024913

P

Seeded From UniProt

complete

DROME:Q86NV3

located_in

GO:0005576: extracellular region

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

DROME:Q86NV3

enables

GO:0048185: activin binding

ECO:0000353: physical interaction evidence used in manual assertion

FB:FBgn0024913

F

Seeded From UniProt

complete


See also

References

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