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PMID:18048693

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Citation

Scheiermann, C, Meda, P, Aurrand-Lions, M, Madani, R, Yiangou, Y, Coffey, P, Salt, TE, Ducrest-Gay, D, Caille, D, Howell, O, Reynolds, R, Lobrinus, A, Adams, RH, Yu, AS, Anand, P, Imhof, BA and Nourshargh, S (2007) Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science 318:1472-5

Abstract

JAM-C is an adhesion molecule that is expressed on cells within the vascular compartment and epithelial cells and, to date, has been largely studied in the context of inflammatory events. Using immunolabeling procedures in conjunction with confocal and electron microscopy, we show here that JAM-C is also expressed in peripheral nerves and that this expression is localized to Schwann cells at junctions between adjoining myelin end loops. Sciatic nerves from JAM-C-deficient [having the JAM-C gene knocked out (KO)] mice exhibited loss of integrity of the myelin sheath and defective nerve conduction as indicated by morphological and electrophysiological studies, respectively. In addition, behavioral tests showed motor abnormalities in the KO animals. JAM-C was also expressed in human sural nerves with an expression profile similar to that seen in mice. These results demonstrate that JAM-C is a component of the autotypic junctional attachments of Schwann cells and plays an important role in maintaining the integrity and function of myelinated peripheral nerves.

Links

PubMed PMC3299566 Online version:10.1126/science.1149276

Keywords

Action Potentials; Animals; Cell Adhesion Molecules/metabolism; Humans; Immunoglobulins/metabolism; Intercellular Junctions/metabolism; Membrane Proteins/metabolism; Mice; Mice, Knockout; Myelin Sheath/metabolism; Myelin Sheath/physiology; Myelin Sheath/ultrastructure; Nerve Fibers, Myelinated/metabolism; Nerve Fibers, Myelinated/physiology; Nerve Fibers, Myelinated/ultrastructure; Neural Conduction; Peripheral Nerves/metabolism; Peripheral Nerves/physiology; Peripheral Nervous System Diseases/metabolism; Peripheral Nervous System Diseases/pathology; Peripheral Nervous System Diseases/physiopathology; Schwann Cells/metabolism; Sciatic Nerve/metabolism; Sciatic Nerve/physiology; Sciatic Nerve/ultrastructure; Sural Nerve/metabolism; Sural Nerve/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:NFASC

located_in

GO:0033010: paranodal junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18577)

Seeded From UniProt

complete

MOUSE:JAM3

acts_upstream_of_or_within

GO:0019226: transmission of nerve impulse

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:JAM3

located_in

GO:0033010: paranodal junction

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18577)

Seeded From UniProt

complete

MOUSE:JAM3

acts_upstream_of_or_within

GO:0042552: myelination

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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