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PMID:18026102

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Citation

Kaeser, SA, Herzig, MC, Coomaraswamy, J, Kilger, E, Selenica, ML, Winkler, DT, Staufenbiel, M, Levy, E, Grubb, A and Jucker, M (2007) Cystatin C modulates cerebral beta-amyloidosis. Nat. Genet. 39:1437-9

Abstract

The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

Links

PubMed Online version:10.1038/ng.2007.23

Keywords

Alzheimer Disease/pathology; Amino Acid Substitution; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Amyloidosis; Animals; Brain/pathology; Cerebrum/metabolism; Cystatin C; Cystatins/genetics; Cystatins/metabolism; Humans; Mice; Mice, Transgenic; Point Mutation

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:CYTC

located_in

GO:0005576: extracellular region

ECO:0000315: mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

HUMAN:CYTC

enables

GO:0001540: amyloid-beta binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P05067

F

Seeded From UniProt

complete

HUMAN:CYTC

involved_in

GO:0097435: supramolecular fiber organization

ECO:0000316: genetic interaction evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:A4

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

UniProtKB:P01034

F

Seeded From UniProt

complete


See also

References

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