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PMID:17994271

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Citation

Timmons, LD (2007) ABC transporters and RNAi in Caenorhabditis elegans. J. Bioenerg. Biomembr. 39:459-63

Abstract

RNAi is an evolutionarily conserved gene-silencing phenomenon that can be triggered by exogenous delivery of double stranded RNA to organisms. In Caenorhabditis elegans, the response to dsRNA is remarkably robust, and systemic RNAi responses are often observed. We have taken a genetic approach using this organism to better understand the mechanisms that facilitate RNAi. By analyzing strains of RNAi-defective mutants, we have uncovered an unexpected role for ABC transporters in RNAi and related silencing mechanisms. Ten of the sixty ABC transporter genes encoded in the C. elegans genome are required for robust RNAi. We will present data that highlights common features of these genes relative to their roles in RNAi, including genetic interactions with other components of the RNAi machinery. We will also describe unique roles for some transporter genes in endogenous RNAi-related processes.

Links

PubMed Online version:10.1007/s10863-007-9121-y

Keywords

ATP-Binding Cassette Transporters/genetics; Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans Proteins/genetics; Gene Silencing; RNA, Small Interfering

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:O44897

involved_in

GO:0016246: RNA interference

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00004324

P

Seeded From UniProt

complete

CAEEL:O44897

involved_in

GO:0016246: RNA interference

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003504

P

Seeded From UniProt

complete

CAEEL:Q8IA64

involved_in

GO:0016246: RNA interference

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00004324

P

Seeded From UniProt

complete

CAEEL:Q8IA64

involved_in

GO:0016246: RNA interference

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003504

P

Seeded From UniProt

complete

CAEEL:Q9BL17

involved_in

GO:0016246: RNA interference

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00004324

P

Seeded From UniProt

complete

CAEEL:Q9BL17

involved_in

GO:0016246: RNA interference

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003504

P

Seeded From UniProt

complete


See also

References

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