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PMID:17981136
Citation |
Joo, E, Surka, MC and Trimble, WS (2007) Mammalian SEPT2 is required for scaffolding nonmuscle myosin II and its kinases. Dev. Cell 13:677-90 |
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Abstract |
Mammalian septin SEPT2 belongs to a conserved family of filamentous GTPases that are associated with actin stress fibers in interphase cells and the contractile ring in dividing cells. Although SEPT2 is essential for cytokinesis, its role in this process remains undefined. Here, we report that SEPT2 directly binds nonmuscle myosin II (myosin II), and this association is important for fully activating myosin II in interphase and dividing cells. Inhibition of the SEPT2-myosin II interaction in interphase cells results in loss of stress fibers, while in dividing cells this causes instability of the ingressed cleavage furrow and dissociation of the myosin II from the Rho-activated myosin kinases ROCK and citron kinase. We propose that SEPT2-containing filaments provide a molecular platform for myosin II and its kinases to ensure the full activation of myosin II that is necessary for the final stages of cytokinesis. |
Links |
PubMed Online version:10.1016/j.devcel.2007.09.001 |
Keywords |
Animals; CHO Cells; Cricetinae; Cricetulus; Cytokinesis; GTP Phosphohydrolases/physiology; Intracellular Signaling Peptides and Proteins/metabolism; Myosin Type II/metabolism; Protein Binding; Protein Folding; Protein-Serine-Threonine Kinases/metabolism; rho-Associated Kinases/metabolism |
Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
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Colocalizes with |
GO:0016460: myosin II complex |
ECO:0000314: |
C |
Cricetulus griseus; Septin-2 (SEPT2) In Figure 1A, immunostaining of myosin-II and SEPT2 in the cells of Chinese hamsters shows that they colocalize. |
complete | |||
Notes
See also
References
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