GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:17961226
| Citation |
Wroble, BN, Finkielstein, CV and Sible, JC (2007) Wee1 kinase alters cyclin E/Cdk2 and promotes apoptosis during the early embryonic development of Xenopus laevis. BMC Dev. Biol. 7:119 |
|---|---|
| Abstract |
The cell cycles of the Xenopus laevis embryo undergo extensive remodeling beginning at the midblastula transition (MBT) of early development. Cell divisions 2-12 consist of rapid cleavages without gap phases or cell cycle checkpoints. Some remodeling events depend upon a critical nucleo-cytoplasmic ratio, whereas others rely on a maternal timer controlled by cyclin E/Cdk2 activity. One key event that occurs at the MBT is the degradation of maternal Wee1, a negative regulator of cyclin-dependent kinase (Cdk) activity. |
| Links |
PubMed PMC2176066 Online version:10.1186/1471-213X-7-119 |
| Keywords |
Animals; Apoptosis/genetics; Blastula/embryology; Blotting, Western; Cell Cycle Proteins/genetics; Cyclin E/genetics; Cyclin-Dependent Kinase 2/antagonists & inhibitors; Cyclin-Dependent Kinase 2/genetics; Embryo, Nonmammalian/cytology; Embryo, Nonmammalian/enzymology; Gene Expression Regulation, Developmental; Protein-Tyrosine Kinases/genetics; RNA, Messenger/genetics; Xenopus Proteins/antagonists & inhibitors; Xenopus Proteins/genetics; Xenopus laevis/embryology; Xenopus laevis/genetics; cdc25 Phosphatases/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0045786: negative regulation of cell cycle |
ECO:0000314: |
P |
Figure 1e |
complete | ||||
|
involved_in |
GO:0045786: negative regulation of cell cycle |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
