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PMID:17940897

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Citation

Rothermel, A, Weigel, W, Pfeiffer-Guglielmi, B, Hamprecht, B and Robitzki, AA (2008) Immunocytochemical analysis of glycogen phosphorylase isozymes in the developing and adult retina of the domestic chicken (Gallus domesticus). Neurochem. Res. 33:336-47

Abstract

Glycogen is the major energy reserve in neural tissues including the retina. A key-enzyme in glycogen metabolism is glycogen phosphorylase (GP) which exists in three differentially regulated isoforms. By applying isozyme-specific antibodies it could be demonstrated that the GP BB (brain), but not the GP MM (muscle) isoform is expressed in the chicken retina in neuronal and glial (Müller) cells. In the embryonic chicken retina, GP showed a development-dependent expression pattern. Double-labeling experiments with cell type-specific antibodies revealed that GP is expressed in various layers of the retina some of which, e.g., the photoreceptor inner segments, are known to be sites of high energy consumption. This suggests important roles of GP BB, and therefore glycogen, in early differentiation, spontaneous wave generation and in formation and stabilization of synapses.

Links

PubMed Online version:10.1007/s11064-007-9477-8

Keywords

Animals; Blotting, Western; Chickens; Glycogen Phosphorylase/metabolism; Immunohistochemistry; Isoenzymes/metabolism; Microscopy, Fluorescence; Retina/enzymology; Retina/growth & development

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:E1BSN7

located_in

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001791)

Seeded From UniProt

complete

CHICK:E1BSN7

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000740)

Seeded From UniProt

complete

CHICK:O42348

located_in

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001791)

Seeded From UniProt

complete

CHICK:Q5ZME4

located_in

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0001791)

Seeded From UniProt

complete

CHICK:Q5ZME4

located_in

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(CL:0000740)

Seeded From UniProt

complete

CHICK:VIME

part_of

GO:0005623: cell

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0011107)

Seeded From UniProt

complete

CHICK:O42348

part_of

GO:0005634: nucleus

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(UBERON:0001791)

Seeded From UniProt

complete

CHICK:Q5ZME4

part_of

GO:0048471: perinuclear region of cytoplasm

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(UBERON:0001791)

Seeded From UniProt

complete

CHICK:Q5ZME4

part_of

GO:0005623: cell

ECO:0000314: direct assay evidence used in manual assertion

C

  • part_of:(UBERON:0000955)
  • part_of:(UBERON:0000948)
  • part_of:(UBERON:0001782)
  • part_of:(UBERON:0001790)
  • part_of:(UBERON:0001789)
  • part_of:(CL:0000561)|part_of:(UBERON:0001792)
  • part_of:(CL:0011107)

Seeded From UniProt

complete

CHICK:Q5ZME4

part_of

GO:0045177: apical part of cell

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(CL:0000740)

Seeded From UniProt

complete

CHICK:Q9PSQ9

part_of

GO:0005623: cell

ECO:0000314: direct assay evidence used in manual assertion

C

part_of:(UBERON:0001134)

Seeded From UniProt

complete

Notes

See also

References

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