PMID:1791839

Citation	Pampfer, S, Tabibzadeh, S, Chuan, FC and Pollard, JW (1991) Expression of colony-stimulating factor-1 (CSF-1) messenger RNA in human endometrial glands during the menstrual cycle: molecular cloning of a novel transcript that predicts a cell surface form of CSF-1. Mol. Endocrinol. 5:1931-8
Abstract	Colony-stimulating factor-1 (CSF-1) has been primarily characterized as a hematopoietic growth factor required for the proliferation and differentiation of monocytic cells. Recent immunohistological observations have shown that this growth factor is also synthesized by the glandular epithelial cells of the pregnant human endometrium and by first trimester human trophoblasts. In the present study endometrial glands were purified from nonpregnant human endometria collected through the menstrual cycle and examined for CSF-1 mRNA expression. The two major mRNAs (4.0 and 3.0 kilobases in length) detected in midproliferative and midsecretory phases differed in the size of the exon 6 and coded, respectively, for a secreted and a cell surface form of CSF-1. The 3.0-kilobase transcript represented a novel CSF-1 mRNA species that was molecularly cloned and sequenced. These data raise the possibility that CSF-1 may be involved in both distant and cell to cell regulatory pathways of cell proliferation and differentiation in the human endometrium.
Links	PubMed
Keywords	Base Sequence; Blotting, Northern; Cell Differentiation/physiology; Cell Division/physiology; Cell Membrane/chemistry; Cells, Cultured; Cloning, Molecular; Endometrium/chemistry; Endometrium/cytology; Endometrium/physiology; Epithelial Cells; Epithelium/chemistry; Epithelium/physiology; Exons; Female; Gene Expression/genetics; Gene Expression/physiology; Humans; Immunohistochemistry; Macrophage Colony-Stimulating Factor/analysis; Macrophage Colony-Stimulating Factor/genetics; Macrophage Colony-Stimulating Factor/physiology; Menstrual Cycle/physiology; Molecular Sequence Data; Polymerase Chain Reaction; RNA, Messenger/analysis; RNA, Messenger/genetics; RNA, Messenger/metabolism; Transcription, Genetic/genetics
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:CSF1	enables	GO:0008083: growth factor activity	ECO:0000303: author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
HUMAN:CSF1	involved_in	GO:0008283: cell population proliferation	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
HUMAN:CSF1	involved_in	GO:0030097: hemopoiesis	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
HUMAN:CSF1	involved_in	GO:0030154: cell differentiation	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete

References

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