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PMID:17822556

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Citation

Gundelach, H, Braas, D and Klempnauer, KH (2007) The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication. BMC Mol. Biol. 8:75

Abstract

The retroviral oncogene v-myb encodes a transcription factor (v-Myb) which is responsible for the transformation of myelomonocytic cells by avian myeloblastosis virus (AMV). v-Myb is thought to exert its biological effects by deregulating the expression of specific target genes. We have recently demonstrated that the chicken Gas41 gene, whose promoter co-localizes with an origin of DNA replication, is a bona fide Myb target gene. Because of this finding we have asked whether other Myb-regulated genes are also associated with DNA replication origins.

Links

PubMed PMC2018721 Online version:10.1186/1471-2199-8-75

Keywords

Animals; Chickens; DNA Replication; DNA-Binding Proteins/genetics; Gene Expression Regulation; Oncogene Proteins v-myb/physiology; Promoter Regions, Genetic; Receptor, Adenosine A2B/genetics; Replication Origin

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CHICK:PRKDC

enables

GO:0005515: protein binding

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

CHICK:MYB

involved_in

GO:0010468: regulation of gene expression

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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