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PMID:17698736

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Citation

Matsui, A, Okigaki, M, Amano, K, Adachi, Y, Jin, D, Takai, S, Yamashita, T, Kawashima, S, Kurihara, T, Miyazaki, M, Tateishi, K, Matsunaga, S, Katsume, A, Honshou, S, Takahashi, T, Matoba, S, Kusaba, T, Tatsumi, T and Matsubara, H (2007) Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function. Circulation 116:1041-51

Abstract

The involvement of Ca2+-dependent tyrosine kinase PYK2 in the Akt/endothelial NO synthase pathway remains to be determined.

Links

PubMed Online version:10.1161/CIRCULATIONAHA.106.645416

Keywords

Analysis of Variance; Animals; Calcium/physiology; Enzyme Activation; Focal Adhesion Kinase 2/deficiency; Focal Adhesion Kinase 2/physiology; Heart/physiology; Hindlimb/blood supply; Ischemia/physiopathology; Mice; Mice, Knockout; Neovascularization, Physiologic/physiology; Nitric Oxide Synthase Type III/metabolism; Oncogene Protein v-akt/physiology; Phosphorylation; Signal Transduction; Vascular Endothelial Growth Factor A/physiology; Vasodilation

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FAK2

involved_in

GO:0010752: regulation of cGMP-mediated signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0010595: positive regulation of endothelial cell migration

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0051000: positive regulation of nitric-oxide synthase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0050848: regulation of calcium-mediated signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:2000249: regulation of actin cytoskeleton reorganization

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0048010: vascular endothelial growth factor receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0045860: positive regulation of protein kinase activity

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0045766: positive regulation of angiogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

MOUSE:FAK2

involved_in

GO:0045428: regulation of nitric oxide biosynthetic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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