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PMID:17645794

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Citation

de Crécy-Lagard, V, El Yacoubi, B, de la Garza, RD, Noiriel, A and Hanson, AD (2007) Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. BMC Genomics 8:245

Abstract

Folate synthesis and salvage pathways are relatively well known from classical biochemistry and genetics but they have not been subjected to comparative genomic analysis. The availability of genome sequences from hundreds of diverse bacteria, and from Arabidopsis thaliana, enabled such an analysis using the SEED database and its tools. This study reports the results of the analysis and integrates them with new and existing experimental data.

Links

PubMed PMC1971073 Online version:10.1186/1471-2164-8-245

Keywords

Anion Transport Proteins; Bacteria/genetics; Bacteria/metabolism; Folic Acid/metabolism; GTP Cyclohydrolase/genetics; Genomics; Metabolic Networks and Pathways/genetics; Peptide Synthases/genetics; Plants/genetics; Plants/metabolism; Pteroylpolyglutamic Acids/metabolism; Transaminases/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

ECOLI:PURU

acts_upstream_of_or_within

GO:0006730: one-carbon metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

ECOLI:PURU

acts_upstream_of_or_within

GO:0009257: 10-formyltetrahydrofolate biosynthetic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

ECOLI:PURU

involved_in

GO:0009257: 10-formyltetrahydrofolate biosynthetic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

ECOLI:PURU

involved_in

GO:0006730: one-carbon metabolic process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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