PMID:17616737

Citation	Dombrecht, B, Xue, GP, Sprague, SJ, Kirkegaard, JA, Ross, JJ, Reid, JB, Fitt, GP, Sewelam, N, Schenk, PM, Manners, JM and Kazan, K (2007) MYC2 differentially modulates diverse jasmonate-dependent functions in Arabidopsis. Plant Cell 19:2225-45
Abstract	The Arabidopsis thaliana basic helix-loop-helix Leu zipper transcription factor (TF) MYC2/JIN1 differentially regulates jasmonate (JA)-responsive pathogen defense (e.g., PDF1.2) and wound response (e.g., VSP) genes. In this study, genome-wide transcriptional profiling of wild type and mutant myc2/jin1 plants followed by functional analyses has revealed new roles for MYC2 in the modulation of diverse JA functions. We found that MYC2 negatively regulates Trp and Trp-derived secondary metabolism such as indole glucosinolate biosynthesis during JA signaling. Furthermore, MYC2 positively regulates JA-mediated resistance to insect pests, such as Helicoverpa armigera, and tolerance to oxidative stress, possibly via enhanced ascorbate redox cycling and flavonoid biosynthesis. Analyses of MYC2 cis binding elements and expression of MYC2-regulated genes in T-DNA insertion lines of a subset of MYC2-regulated TFs suggested that MYC2 might modulate JA responses via differential regulation of an intermediate spectrum of TFs with activating or repressing roles in JA signaling. MYC2 also negatively regulates its own expression, and this may be one of the mechanisms used in fine-tuning JA signaling. Overall, these results provide new insights into the function of MYC2 and the transcriptional coordination of the JA signaling pathway.
Links	PubMed PMC1955694 Online version:10.1105/tpc.106.048017
Keywords	Animals; Arabidopsis/drug effects; Arabidopsis/genetics; Arabidopsis/metabolism; Arabidopsis Proteins/chemistry; Arabidopsis Proteins/genetics; Arabidopsis Proteins/metabolism; Base Sequence; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/chemistry; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/genetics; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors/metabolism; Biological Transport/drug effects; Cyclopentanes/metabolism; Cyclopentanes/pharmacology; Defensins/metabolism; Down-Regulation/drug effects; Flavonoids/biosynthesis; Gene Expression Regulation, Plant/drug effects; Genes, Plant; Glucosinolates/biosynthesis; Immunity, Innate/drug effects; Indoleacetic Acids/metabolism; Insects; Molecular Sequence Data; Oxidative Stress/drug effects; Oxylipins/metabolism; Oxylipins/pharmacology; Plant Diseases/immunology; Plant Diseases/parasitology; Plant Roots/drug effects; Plant Roots/metabolism; Protein Binding/drug effects; Regulatory Sequences, Nucleic Acid/genetics; Signal Transduction/drug effects; Transcription, Genetic/drug effects; Tryptophan/metabolism
edit table

Annotations

Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
edit table

References

See Help:References for how to manage references in GONUTS.