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PMID:17506990

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Citation

Choy, SW, Wong, YM, Ho, SH and Chow, KL (2007) C. elegans SIN-3 and its associated HDAC corepressor complex act as mediators of male sensory ray development. Biochem. Biophys. Res. Commun. 358:802-7

Abstract

Mab21 gene family members are required for embryonic development and sensory organ formation in both invertebrates and vertebrates. However, their mechanistic role on differentiation is largely unexplored. We report here the isolation of SIN-3 as a MAB-21 interacting molecule. sin-3 is co-expressed with mab-21 in the ray structural cells and genetically interacts with mab-21 to control sensory organ development. Using pharmacological and RNAi approaches, we demonstrated that histone deacetylase and conserved SIN-3-associated components are required for ray patterning. Conserved physical interactions between these components were also observed, implicating the recruitment of HDAC complex by MAB-21/SIN-3 may occur to determine ray identity in males.

Links

PubMed Online version:10.1016/j.bbrc.2007.04.194

Keywords

Amino Acid Sequence; Animals; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/metabolism; Chromatin Assembly and Disassembly; Gene Expression Regulation, Developmental; Genotype; Histone Deacetylases/metabolism; Hydroxamic Acids/metabolism; Male; Models, Genetic; Molecular Sequence Data; Neuropeptides/metabolism; RNA Interference; Sin3 Histone Deacetylase and Corepressor Complex; Transforming Growth Factor beta/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:SIN3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00003036

F

Seeded From UniProt

complete

CAEEL:SIN3

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00001194

F

Seeded From UniProt

complete

CAEEL:SIN3

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00250282

P

Seeded From UniProt

complete

CAEEL:SIN3

contributes_to

GO:0004407: histone deacetylase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

CAEEL:SIN3

involved_in

GO:0090597: nematode male tail mating organ morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00250282

P

Seeded From UniProt

complete

CAEEL:SIN3

involved_in

GO:0090597: nematode male tail mating organ morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

WB:WBGene00003112

P

Seeded From UniProt

complete

CAEEL:SIN3

involved_in

GO:0040025: vulval development

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00250282

P

Seeded From UniProt

complete

CAEEL:SIN3

involved_in

GO:0040011: locomotion

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00250282

P

Seeded From UniProt

complete

CAEEL:HDA1

involved_in

GO:0045138: nematode male tail tip morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:LIN53

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00004312

F

Seeded From UniProt

complete

CAEEL:LIN53

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:LIN53

involved_in

GO:0045138: nematode male tail tip morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:RBA1

enables

GO:0005515: protein binding

ECO:0000353: physical interaction evidence used in manual assertion

WB:WBGene00003036

F

Seeded From UniProt

complete

CAEEL:RBA1

involved_in

GO:0001708: cell fate specification

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:RBA1

involved_in

GO:0045138: nematode male tail tip morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:EGL27

involved_in

GO:0045138: nematode male tail tip morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:HDA2

involved_in

GO:0045138: nematode male tail tip morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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