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PMID:17498703

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Citation

Friedberg, I, Nika, K, Tautz, L, Saito, K, Cerignoli, F, Friedberg, I, Godzik, A and Mustelin, T (2007) Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. FEBS Lett. 581:2527-33

Abstract

A novel human dual-specific protein phosphatase (DSP), designated DUSP27, is here described. The DUSP27 gene contains three exons, rather than the predicted 4-14 exons, and encodes a 220 amino acid protein. DUSP27 is structurally similar to other small DSPs, like VHR and DUSP13. The location of DUSP27 on chromosome 10q22, 50kb upstream of DUSP13, suggests that these two genes arose by gene duplication. DUSP27 is an active enzyme, and its kinetic parameters and were determined. DUSP27 is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism.

Links

PubMed Online version:10.1016/j.febslet.2007.04.059

Keywords

Adipose Tissue/enzymology; Base Sequence; Conserved Sequence; Cytosol/enzymology; DNA/chemistry; DNA/genetics; Dual-Specificity Phosphatases; Energy Metabolism; Evolution, Molecular; Exons; Humans; Liver/enzymology; Molecular Sequence Data; Muscle, Skeletal/enzymology; Phosphoprotein Phosphatases/genetics; Phosphoprotein Phosphatases/metabolism; Plasmids; Polymerase Chain Reaction; Protein Tyrosine Phosphatases/genetics; Protein Tyrosine Phosphatases/metabolism; Recombinant Proteins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:DUS1

enables

GO:0008138: protein tyrosine/serine/threonine phosphatase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:DUS29

involved_in

GO:0006470: protein dephosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DUS29

enables

GO:0008138: protein tyrosine/serine/threonine phosphatase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:DUS23

enables

GO:0008138: protein tyrosine/serine/threonine phosphatase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:DUS15

enables

GO:0008138: protein tyrosine/serine/threonine phosphatase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:DUPD1

enables

GO:0008138: protein tyrosine/serine/threonine phosphatase activity

ECO:0000314: direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

HUMAN:DUPD1

involved_in

GO:0006470: protein dephosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:DUPD1

GO:0008138: protein tyrosine/serine/threonine phosphatase activity

ECO:0000314:

F

Figures 4B & 4D.

complete


See also

References

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