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PMID:17488184

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Citation

Grönke, S, Müller, G, Hirsch, J, Fellert, S, Andreou, A, Haase, T, Jäckle, H and Kühnlein, RP (2007) Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biol. 5:e137

Abstract

Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ss-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis.

Links

PubMed PMC1865564 Online version:10.1371/journal.pbio.0050137

Keywords

Animals; Drosophila/genetics; Drosophila/metabolism; Energy Metabolism/physiology; Homeostasis/physiology; Lipase/genetics; Lipase/metabolism; Lipolysis/physiology; Mutation; Receptors, LHRH/genetics; Receptors, LHRH/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:E1JI03

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:E1JI03

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O77152

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O77152

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q71EB3

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q71EB3

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KTL9

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q7KTL9

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95T55

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q95T55

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VM96

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VM96

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VUH7

involved_in

GO:0016042: lipid catabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VUH7

involved_in

GO:0055088: lipid homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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