GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:17464331
Citation |
Nakade, K, Pan, J, Yoshiki, A, Ugai, H, Kimura, M, Liu, B, Li, H, Obata, Y, Iwama, M, Itohara, S, Murata, T and Yokoyama, KK (2007) JDP2 suppresses adipocyte differentiation by regulating histone acetylation. Cell Death Differ. 14:1398-405 |
---|---|
Abstract |
Among the events that control cellular differentiation, the acetylation of histones plays a critical role in the regulation of transcription and the modification of chromatin. Jun dimerization protein 2 (JDP2), a member of the AP-1 family, is an inhibitor of such acetylation and contributes to the maintenance of chromatin structure. In an examination of Jdp2 'knock-out' (KO) mice, we observed elevated numbers of white adipocytes and significant accumulation of lipid in the adipose tissue in sections of scapulae. In addition, mouse embryo fibroblasts (MEFs) from Jdp2 KO mice were more susceptible to adipocyte differentiation in response to hormonal induction and members of the CCAAT/enhancer-binding proteins (C/EBP) gene family were expressed at levels higher than MEFs from wild-type mice. Furthermore, JDP2 inhibited both the acetylation of histone H3 in the promoter of the gene for C/EBPdelta and transcription from this promoter. Our data indicate that JDP2 plays a key role as a repressor of adipocyte differentiation by regulating the expression of the gene for C/EBPdelta via inhibition of histone acetylation. |
Links |
PubMed Online version:10.1038/sj.cdd.4402129 |
Keywords |
3T3-L1 Cells; Acetylation; Adipocytes/cytology; Adipocytes/metabolism; Adipogenesis/genetics; Adipogenesis/physiology; Animals; Base Sequence; CCAAT-Enhancer-Binding Protein-delta/genetics; Cell Differentiation/physiology; DNA Primers/genetics; Female; Fibroblasts/cytology; Fibroblasts/metabolism; Gene Targeting; Histones/chemistry; Histones/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Pregnancy; Promoter Regions, Genetic; Repressor Proteins/genetics; Repressor Proteins/physiology |
edit table |
Significance
Annotations
Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|
MOUSE:HDAC3 |
involved_in |
GO:0016575: histone deacetylation |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1932093 |
P |
Seeded From UniProt |
complete | |
MOUSE:JDP2 |
enables |
GO:0003682: chromatin binding |
ECO:0000314: direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | ||
MOUSE:JDP2 |
involved_in |
GO:0045444: fat cell differentiation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
MOUSE:JDP2 |
involved_in |
GO:0045599: negative regulation of fat cell differentiation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | ||
MOUSE:JDP2 |
located_in |
GO:0005634: nucleus |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | ||
MOUSE:JDP2 |
involved_in |
GO:0031065: positive regulation of histone deacetylation |
ECO:0000316: genetic interaction evidence used in manual assertion |
MGI:MGI:1343091 |
P |
Seeded From UniProt |
complete | |
See also
References
See Help:References for how to manage references in GONUTS.