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PMID:17460067

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Citation

Urizar, NL, Yang, Z, Edenberg, HJ and Davis, RL (2007) Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. J. Neurosci. 27:4541-51

Abstract

The molecular mechanisms occurring in the nervous system that underlie behavioral responses to ethanol remain poorly understood. Here, we report that molecular requirements for two of these responses, initial sensitivity and the development of rapid tolerance, comap to the same small set of neurons. We show that null homer mutant flies exhibit both increased sensitivity to the sedative effects of ethanol and failure to develop normal levels of rapid tolerance. Both the sensitivity and rapid tolerance phenotypes of the homer mutants are rescued by the expression of wild-type homer in a subset of neurons that include the ellipsoid body. Thus, some of the molecular- and systems-level requirements for these two behavioral responses to ethanol are identical.

Links

PubMed Online version:10.1523/JNEUROSCI.0305-07.2007

Keywords

Animals; Animals, Genetically Modified; Brain/cytology; Brain/drug effects; Brain/physiology; Carrier Proteins/genetics; Carrier Proteins/physiology; Central Nervous System Depressants/pharmacokinetics; Central Nervous System Depressants/pharmacology; DNA-Binding Proteins; Drosophila Proteins/genetics; Drosophila Proteins/physiology; Drosophila melanogaster; Drug Resistance/genetics; Drug Tolerance/genetics; Ethanol/pharmacokinetics; Ethanol/pharmacology; Male; Neurons/drug effects; Neurons/physiology; Oligonucleotide Array Sequence Analysis; Phenotype; Saccharomyces cerevisiae Proteins/genetics; Transcription Factors/genetics

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:M9PB54

involved_in

GO:0048149: behavioral response to ethanol

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:M9PB54

involved_in

GO:0045471: response to ethanol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:M9PEX1

involved_in

GO:0048149: behavioral response to ethanol

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:M9PEX1

involved_in

GO:0045471: response to ethanol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O96607

involved_in

GO:0048149: behavioral response to ethanol

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:O96607

involved_in

GO:0045471: response to ethanol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q0E8S7

involved_in

GO:0048149: behavioral response to ethanol

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q0E8S7

involved_in

GO:0045471: response to ethanol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VM94

involved_in

GO:0048149: behavioral response to ethanol

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9VM94

involved_in

GO:0045471: response to ethanol

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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