GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:17426285

From GONUTS
Jump to: navigation, search
Citation

Kita, A, Imayoshi, I, Hojo, M, Kitagawa, M, Kokubu, H, Ohsawa, R, Ohtsuka, T, Kageyama, R and Hashimoto, N (2007) Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol. Endocrinol. 21:1458-66

Abstract

The pituitary gland is composed of two distinct entities: the adenohypophysis, including the anterior and intermediate lobes, and the neurohypophysis, known as the posterior lobe. This critical endocrine organ is essential for homeostasis, metabolism, reproduction, and growth. The pituitary development requires the control of proliferation and differentiation of progenitor cells. Although multiple signaling molecules and transcription factors are required for the proper pituitary development, the mechanisms that regulate the fate of progenitor cells remain to be elucidated. Hes genes, known as Notch effectors, play a crucial role in specifying cellular fates during the development of various tissues and organs. Here, we report that mice deficient for Hes1 and Hes5 display severe pituitary hypoplasia caused by accelerated differentiation of progenitor cells. In addition, this hypoplastic pituitary gland (adenohypophysis) lacks the intermediate lobe and exhibits the features of the anterior lobe only. Hes1 and Hes5 double-mutant mice also lack the neurohypophysis (the posterior lobe), probably due to incomplete evagination of the diencephalon. Thus, Hes genes control not only maintenance of progenitor cells but also intermediate vs. anterior lobe specification during the adenohypophysis development. Hes genes are also essential for the formation of the neurohypophysis.

Links

PubMed Online version:10.1210/me.2007-0039

Keywords

Animals; Basic Helix-Loop-Helix Transcription Factors/analysis; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Cell Differentiation/genetics; Homeodomain Proteins/analysis; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Mice; Mice, Mutant Strains; Organogenesis/genetics; Pituitary Gland, Posterior/abnormalities; Pituitary Gland, Posterior/growth & development; Pituitary Gland, Posterior/metabolism; Repressor Proteins/analysis; Repressor Proteins/genetics; Repressor Proteins/metabolism; Stem Cells/cytology; Stem Cells/metabolism; Stem Cells/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:HES1

acts_upstream_of_or_within

GO:0021983: pituitary gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2149672

P

  • results_in_development_of:(EMAPA:16898)

Seeded From UniProt

complete

MOUSE:HES1

acts_upstream_of_or_within

GO:0021983: pituitary gland development

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:104876

P

  • results_in_development_of:(EMAPA:16898)

Seeded From UniProt

complete

MOUSE:HES1

acts_upstream_of_or_within

GO:0008284: positive regulation of cell population proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2149672

P

  • regulates_o_occurs_in:(EMAPA:16898)

Seeded From UniProt

complete

MOUSE:HES1

acts_upstream_of_or_within

GO:0045596: negative regulation of cell differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2149672

P

  • occurs_in:(EMAPA:16898)

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.